RT Journal Article
T1 Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis.
A1 Minina, Alyona
A1 Sánchez-Vera, Victoria
A1 Moschou, Panagiotis N.
A1 Suárez-Marín, María Fernanda
A1 Sundberg, Eva
A1 Weih, Martin
A1 Bozhkov, Peter V.
K1 Arabidopsis thaliana - Envejecimiento
K1 Metabolismo
K1 Plantas - Longevidad
AB Caloric restriction (CR) extends lifespan in various heterotrophic organisms ranging from yeasts to mammals, but whether a similar phenomenon occurs in plants remains unknown. Plants are autotrophs and use their photosynthetic machinery to convert light energy into the chemical energy of glucose and other organic compounds. As the rate of photosynthesis is proportional to the level of photosynthetically active radiation, the CR in plants can be modeled by lowering light intensity. Here, we report that low light intensity extends the lifespan in Arabidopsis through the mechanisms triggering autophagy, the major catabolic process that recycles damaged and potentially harmful cellular material. Knockout of autophagy-related genes results in the short lifespan and suppression of the lifespan-extending effect of the CR. Our data demonstrate that the autophagy-dependent mechanism of CR induced lifespan extension is conserved between autotrophs and heterotrophs.
PB Aging Cell/Blackwell publishing Ltd/Anatomical Society of Great Britain and Ireland
YR 2013
FD 2013-01-17
LK https://hdl.handle.net/10630/34353
UL https://hdl.handle.net/10630/34353
LA eng
NO Minina, E. A., Sanchez‐Vera, V., Moschou, P. N., Suarez, M. F., Sundberg, E., Weih, M., & Bozhkov, P. v. (2013). Autophagy mediates caloric restriction‐induced lifespan extension in Arabidopsis. Aging Cell, 12(2), 327–329.
NO This work was supported by the Swedish Research Council, Pehrssons Fund, the Swedish Foundation for Strategic Research, Olle Engkvist Foundation and the Spanish Ministry of Science and Innovation. V.S-V was a recipient of a FPI fellowship from the Spanish Ministry of Science and Innovation (BES-2008-00359
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026