RT Journal Article
T1 RGS14414-Mediated Activation of the 14-3-3ζ in Rodent Perirhinal Cortex Induces Dendritic Arborization, an Increase in Spine Number, Long-Lasting Memory Enhancement, and the Prevention of Memory Deficits
A1 Navarro-Lobato, Irene
A1 Masmudi-Martín, Mariam
A1 López-Aranda, Manuel Francisco
A1 Quirós-Ortega, María Elena
A1 Carretero-Rey, Marta
A1 García-Garrido, María F.
A1 Gallardo-Martínez, Carmen
A1 Martín-Montañez, Elisa
A1 Gaona-Romero, Celia
A1 Delgado, Gloria
A1 Torres-Garcia, Laura
A1 Terrón-Melguizo, Javier
A1 Posadas, Sinforiano
A1 Rodríguez Muñoz, Lourdes
A1 Vivar Rios, Carlos
A1 Zoidakis, Jerome
A1 Vlahou, Antonia
A1 López, Juan C.
A1 Khan, Zafaruddin
K1 Neurociencia cognitiva
K1 Memoria - Trastornos
AB The remedy of memory deficits has been inadequate, as all potential candidates studied thus far have shown limited to no effects and a search for an effective strategy is ongoing. Here, we show that an expression of RGS14414 in rat perirhinal cortex (PRh) produced long-lasting object recognition memory (ORM) enhancement and that this effect was mediated through the upregulation of 14-3-3ζ, which caused a boost in BDNF protein levels and increase in pyramidal neuron dendritic arborization and dendritic spine number. A knockdown of the 14-3-3ζ gene in rat or the deletion of the BDNF gene in mice caused complete loss in ORM enhancement and increase in BDNF protein levels and neuronal plasticity, indicating that 14-3-3ζ-BDNF pathway-mediated structural plasticity is an essential step in RGS14414-induced memory enhancement. We further observed that RGS14414 treatment was able to prevent deficits in recognition, spatial, and temporal memory, which are types of memory that are particularly affected in patients with memory dysfunctions, in rodent models of aging and Alzheimer's disease. These results suggest that 14-3-3ζ-BDNF pathway might play an important role in the maintenance of the synaptic structures in PRh that support memory functions and that RGS14414-mediated activation of this pathway could serve as a remedy to treat memory deficits.
PB Oxford University Press
YR 2022
FD 2022
LK https://hdl.handle.net/10630/39414
UL https://hdl.handle.net/10630/39414
LA eng
NO Navarro-Lobato I, Masmudi-Martín M, López-Aranda MF, et al. RGS14414-Mediated Activation of the 14-3-3ζ in Rodent Perirhinal Cortex Induces Dendritic Arborization, an Increase in Spine Number, Long-Lasting Memory Enhancement, and the Prevention of Memory Deficits. Cereb Cortex. 2022;32(9):1894-1910. doi:10.1093/cercor/bhab322
NO https://openpolicyfinder.jisc.ac.uk/id/publication/250
NO Ministerio de Economía y Competitividad (BFU2013-43458-R); Junta de Andalucía (P12-CTS-1694, PI-0542-2013 to Z.U.K.)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026