RT Journal Article
T1 Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
A1 Cheng-Sánchez, Iván
A1 Sánchez-Ruiz, Antonio
A1 Martínez-Póveda, Beatriz Amparo
A1 Medina-Torres, Miguel Ángel
A1 Carrillo Fernández, Paloma
A1 Rodríguez-Quesada, Ana María
A1 López-Romero, Juan Manuel
A1 Sarabia-García, Francisco Ramón
K1 Cáncer
AB New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized systems, and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core. The described synthetic strategies toward the solomonamides are well suited for the subsequent access to the natural products and represent flexible and diversityoriented routes that allow for the generation of a variety of analogues via oxidative transformations. In addition, preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines.
YR 2018
FD 2018-10-19
LK https://hdl.handle.net/10630/16666
UL https://hdl.handle.net/10630/16666
LA eng
NO This work was financially supported by the Ministerio de Economía y Competitividad (MINECO) (ref BIO2014-56092-R, CTQ2014-60223-R and CTQ2016-76311-R) and Junta de Andalucía and “Fondo Europeo de Desarrollo Regional-FEDER” (P12CTS-1507). I.C.-S. thanks Ministerio de Educación, Cultura y Deporte for a predoctoral fellowship (FPU programme).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026