RT Journal Article T1 Does tension headache have a central or peripheral origin? Current state of affairs A1 Repiso-Guardeño, Angela A1 Moreno-Morales, Noelia A1 Labajos-Manzanares, María Teresa A1 Rodríguez-Martínez, María del Carmen A1 Armenta-Peinado, Juan Antonio K1 Cefalea - Fisiopatología K1 Dolor - Aspectos fisiológicos K1 Sistema nervioso - Enfermedades AB Purpose of Review The aim of this narrative review is to analyze the evidence about a peripheral or central origin of a ten-sion headache attack in order to provide a further clarification for an appropriate approach.Recent Findings Tension headache is a complex and multifactorial pathology, in which both peripheral and central factors could play an important role in the initiation of an attack. Although the exact origin of a tension headache attack has not been conclusively established, correlations have been identified between certain structural parameters of the craniomandibular region and craniocervical muscle activity. Future research should focus on improving our understanding of the pathology with the ultimate goal of improving diagnosis.Summary The pathogenesis of tension-type headache involves both central and peripheral mechanisms, being the perpetu-ation over time of the headache attacks what would favor the evolution of an episodic tension-type headache to a chronic tension-type headache. The unresolved question is what factors would be involved in the initial activation in a tension head-ache attack. The evidence that favors a peripheral origin of the tension headache attacks, that is, the initial events occur outside the brain barrier, which suggests the action of vascular and musculoskeletal factors at the beginning of a tension headache attack, factors that would favor the sensitization of the peripheral nervous system as a result of sustained sensory input. PB Springer Nature YR 2023 FD 2023-10-27 LK https://hdl.handle.net/10630/28082 UL https://hdl.handle.net/10630/28082 LA eng NO Repiso-Guardeño, Á., Moreno-Morales, N., Labajos-Manzanares, M.T. et al. Does Tension Headache Have a Central or Peripheral Origin? Current State of Affairs. Curr Pain Headache Rep (2023). https://doi.org/10.1007/s11916-023-01179-2 NO Funding for open access charge: Universidad de Málaga / CBUA DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026