RT Journal Article
T1 Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis.
A1 Ciano-Petersen, Nicolas Lundahl
A1 Mélisse, Robert
A1 Muñiz-Castrillo, Sergio
A1 Wucher, Valentin
A1 Klich, Amna
A1 Alberto Vogrig, Alberto
A1 Villagrán García, Macarena
A1 Antonio Farina, Antonio
A1 David Goncalves, David
A1 Geraldine Picard, Geraldine
A1 Veronique Rogemond, Veronique
A1 Bastien Joubert, Bastien
A1 Oliver-Martos, Begoña
A1 Serrano-Castro, Pedro Jesús
A1 Maucort-Boulch, Delphine
A1 Honnorat, Jerome
K1 Encefalitis
AB Background and objectives: Anti-NMDA receptor (NMDAR) encephalitis is defined by the presence of antibodies (Abs) targeting the NMDAR in the CSF. This study aimed to determine the prognostic value of persistent CSF NMDAR-Abs during follow-up.Methods: This retrospective observational study included patients diagnosed with anti-NMDAR encephalitis in the French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis and for whom CSF samples were obtained at diagnosis and >4 months of follow-up to evaluate CSF NMDAR-Ab persistence. Because patients were tested for CSF NMDAR-Abs at different time points, samples were stratified into different periods of follow-up (i.e., 12 months was considered for the 9- to 16-month follow-up period).Results: Among the 501 patients diagnosed with anti-NMDAR encephalitis between January 2007 and June 2020, 89 (17%) were tested between 4 and 120 months for CSF NMDAR-Abs after clinical improvement and included in the study (75/89 women, 84%; median age 20 years, interquartile range [IQR] 16-26). During follow-up, 21 of 89 (23%) patients had a relapse after a median time of 29 months (IQR 18-47), and 20 of 89 (22%) had a poor outcome (mRS ≥3) after a median last follow-up of 36 months (IQR 19-64). Most patients (69/89, 77%) were tested at the 12-month follow-up period, and 42 of 69 (60%) of them had persistent CSF NMDAR-Abs. When comparing patients with persistent or absent CSF NMDAR-Abs at 12 months, poor outcome at the last follow-up was more frequent in the former (38% vs 8%, p = 0.01), who had relapses more often (23% vs 7%), which also appeared earlier in the course of the disease (90% during the following 4 years of follow-up vs 20%), although no significant difference was observed at long-term follow-up (p = 0.15). In addition, patients with persistent CSF NMDAR-Abs at 12 months had higher titers of CSF NMDAR-Abs at diagnosis
PB American Academy of Neurology
YR 2023
FD 2023-05-05
LK https://hdl.handle.net/10630/37144
UL https://hdl.handle.net/10630/37144
LA eng
NO Ciano-Petersen NL, Robert M, Muñiz-Castrillo S, Wucher V, Klich A, Vogrig A, Villagrán García M, Farina A, Goncalves D, Picard G, Rogemond V, Joubert B, Oliver-Martos B, Serrano-Castro PJ, Maucort-Boulch D, Honnorat J. Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2023 May 5;10(4):e200108. doi: 10.1212/NXI.0000000000200108. PMID: 37147137; PMCID: PMC10162705.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026