RT Journal Article
T1 Functional objective parameters which may discriminate patients with mild cognitive impairment from cognitively healthy individuals: a systematic review and meta-analysis using an instrumented kinematic assessment.
A1 Fuentes-Abolafio, Iván José
A1 Stubbs, Brendon
A1 Pérez-Belmonte, Luis Miguel
A1 Bernal-López, María Rosa
A1 Gómez-Huelgas, Ricardo
A1 Cuesta-Vargas, Antonio
K1 Trastornos cognitivos
AB Background: a systematic review in 2015 showed kinematic gait and balance parameters which can discriminate patients with mild cognitive impairment (MCI) from cognitively healthy individuals.Objective: this systematic review and meta-analysis aims to summarise and synthesise the evidence published after the previous review about the functional objective parameters obtained by an instrumented kinematic assessment which could discriminate patients with MCI from cognitively healthy individuals, as well as to assess the level of evidence per outcome.Methods: major electronic databases were searched from inception to August 2019 for cross-sectional studies published after 2015 examining kinematic gait and balance parameters, which may discriminate patients with MCI from cognitively healthy individuals. Meta-analysis was carried out for each parameter reported in two or more studies.Results: Ten cross-sectional studies with a total of 1,405 patients with MCI and 2,277 cognitively healthy individuals were included. Eight of the included studies reported a low risk of bias. Patients with MCI showed a slower gait speed than cognitively healthy individuals. Thus, single-task gait speed (d = -0.44, 95%CI [-0.60 to -0.28]; P < 0.001), gait speed at fast pace (d = -0.48, 95%CI [-0.72 to -0.24]; P < 0.001) and arithmetic dual-task gait speed (d = -1.20, 95%CI [-2.12 to -0.28]; P = 0.01) were the functional objective parameters which best discriminated both groups.Conclusion: the present review shows kinematic gait parameters which may discriminate patients with MCI from cognitively healthy individuals. Most of the included studies reported a low risk of bias, but the grading of recommendations assessment, development and evaluation criteria showed a low level of evidence per outcome.
PB Oxford University Press
YR 2021
FD 2021
LK https://hdl.handle.net/10630/36342
UL https://hdl.handle.net/10630/36342
LA eng
NO Fuentes-Abolafio IJ, Stubbs B, Pérez-Belmonte LM, Bernal-López MR, Gómez-Huelgas R, Cuesta-Vargas A. Functional objective parameters which may discriminate patients with mild cognitive impairment from cognitively healthy individuals: a systematic review and meta-analysis using an instrumented kinematic assessment. Age Ageing. 2021 Feb 26;50(2):380-393. doi: 10.1093/ageing/afaa135. PMID: 33000147.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/1334
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026