RT Journal Article
T1 Normothermic Regional Perfusion vs. Super-Rapid Recovery in Controlled Donation After Circulatory Death Liver Transplantation
A1 Hessheimer, Amelia J.
A1 Coll, Elisabeth
A1 Torres, Ferrán
A1 Ruiz, Patricia
A1 Gastaca, Mikel
A1 Rivas, José Ignacio
A1 Gómez, Manuel
A1 Sánchez-Pérez, Belinda
A1 Santoyo, Julio
A1 Ramírez, Pablo
A1 Parrilla, Pascual
A1 Marín, Luis Miguel
A1 Gomez-Bravo, Miguel Angel
A1 García-Valdecasas, Juan Carlos
A1 López-Monclús, Javier López
A1 Boscá, Andrea
A1 López-Andujar, Rafael
A1 Fundora-Suárez, Jiliam
A1 Villar, Jesús
A1 García-Sesma, Alvaro
A1 Jiménez, Carlos
A1 Rodríguez-Laíz, Gonzalo
A1 LLadó, Laura
A1 Rodríguez, Juan Carlos
A1 Barrera, Manuel
A1 Charco, Ramón
A1 López-Baena, Jose Ángel
A1 Briceño, Javier
A1 Pardo, Fernando
A1 Blanco, Gerardo
A1 Pacheco, David
A1 Domínguez-Gil, Beatriz
A1 Sánchez Turrión, Víctor
A1 Fondevila, Constatino
A1 rivas, jose ignacio
K1 Hígado - Trasplante
AB Background & Aims: Although there is increasing interest in itsuse, definitive evidence demonstrating a benefit for postmortemnormothermic regional perfusion (NRP) in controlled donationafter circulatory death (cDCD) liver transplantation is lacking.The aim of this study was to compare results of cDCD livertransplants performed with postmortem NRP vs. super-rapidrecovery (SRR), the current standard for cDCD.Methods: This was an observational cohort study including allcDCD liver transplants performed in Spain between June 2012and December 2016, with follow-up ending in December2017. Each donor hospital determined whether organ recoverywas performed using NRP or SRR. The propensity scores techniquebased on the inverse probability of treatment weighting(IPTW) was used to balance covariates across study groups;logistic and Cox regression models were used for binary andtime-to-event outcomes.Results: During the study period, there were 95 cDCD livertransplants performed with postmortem NRP and 117 withSRR. The median donor age was 56 years (interquartile range45–65 years). After IPTW analysis, baseline covariates were balanced,with all absolute standardised differences <0.15. IPTWadjustedrisks were significantly improved among NRP liversfor overall biliary complications (odds ratio 0.14; 95% CI 0.06–0.35, p <0.001), ischaemic type biliary lesions (odds ratio 0.11;95% CI 0.02–0.57; p = 0.008), and graft loss (hazard ratio 0.39;95% CI 0.20–0.78; p = 0.008).Conclusions: The use of postmortem NRP in cDCD liver transplantationappears to reduce postoperative biliary complications,ischaemic type biliary lesions and graft loss, and allowsfor the transplantation of livers even from cDCD donors ofadvanced age.
PB Elsevier
YR 2019
FD 2019
LK https://hdl.handle.net/10630/41363
UL https://hdl.handle.net/10630/41363
LA eng
NO Hessheimer AJ, Coll E, Torres F, Ruíz P, Gastaca M, Rivas JI, Gómez M, Sánchez B, Santoyo J, Ramírez P, Parrilla P, Marín LM, Gómez-Bravo MÁ, García-Valdecasas JC, López-Monclús J, Boscá A, López-Andújar R, Fundora-Suárez J, Villar J, García-Sesma Á, Jiménez C, Rodríguez-Laíz G, Lladó L, Rodríguez JC, Barrera M, Charco R, López-Baena JÁ, Briceño J, Pardo F, Blanco G, Pacheco D, Domínguez-Gil B, Sánchez Turrión V, Fondevila C. Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation. J Hepatol. 2019 Apr;70(4):658-665. doi: 10.1016/j.jhep.2018.12.013. Epub 2018 Dec 22. PMID: 30582980.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026