RT Journal Article
T1 Holistic Photoprotection, Broad Spectrum (UVA-UVB), and Biological Effective Protection Factors (BEPFs) from Baccharis antioquensis Hydrolysates Polyphenols
A1 Monsalve-Bustamante, Yéssica A
A1 López-Figueroa, Félix
A1 Vega Sánchez, Julia
A1 Rodrigues Moreira, Bruna
A1 Puertas-Mejía, Miguel
A1 Mejía-Giraldo, Juan C.
K1 Piel -- Efectos de la radiación -- Protección
K1 Rayos ultravioletas -- Protección
K1 Radiación solar -- Protección
AB Overexposure to solar radiation has become an increasingly worrying problem due to the damage to the skin caused by ultraviolet  radiation (UVR). In previous studies, the potential of an extract enriched with glycosylated flavonoids from the endemic Colombian high-mountain plant Baccharis antioquensis as a photoprotector and antioxidant was demonstrated. Therefore, in this work we sought to develop a dermocosmetic formulation with broad-spectrum photoprotection from the hydrolysates and purified polyphenols obtained from this species. Hence, the extraction of its polyphenols with different solvents was evaluated, followed by hydrolysis and purification, in addition to the characterization of its main compounds by HPLC–DAD and HPLC–MS, and evaluation of its photoprotective capacity through the measurement of the Sun Protection Factor (SPF), UVA Protection Factor (UVAPF), other Biological Effective Protection Factors (BEPFs), and its safety through the cytotoxicity. In the dry methanolic extract (DME) and purified methanolic extract (PME), flavonoids such as quercetin and kaempferol were found, which demonstrated antiradical capacity, as well as UVA–UVB photoprotection and prevention of harmful biological effects, such as elastosis, photoaging, immunosuppression, DNA damage, among others, which demonstrates the potential of the ingredients in this type of extract to be applied in photoprotection dermocosmetics.
PB MDPI
YR 2023
FD 2023-02-21
LK https://hdl.handle.net/10630/26607
UL https://hdl.handle.net/10630/26607
LA eng
NO Monsalve-Bustamante YA, Figueroa FL, Vega J, Moreira BR, Puertas-Mejía M, Mejía-Giraldo JC. Holistic Photoprotection, Broad Spectrum (UVA-UVB), and Biological Effective Protection Factors (BEPFs) from Baccharis antioquensis Hydrolysates Polyphenols. Plants. 2023; 12(5):979. https://doi.org/10.3390/plants12050979
NO The authors acknowledge CODI-Universidad de Antioquia (Project No. CIQF 290) for financial support. The authors would like to thank the International Passages Support Fund Universidad de Antioquia. The research was financed partially by NAZCA Project (P20-00458) by Andalusian Government. Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026