RT Journal Article
T1 Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention
A1 Escriche-Escuder, Adrian
A1 Trinidad-Fernández, Manuel
A1 Pajares, Bella
A1 Iglesias-Campos, Marcos
A1 Alba-Conejo, Emilio
A1 Cuesta-Vargas, Antonio
A1 Roldán-Jiménez, Cristina
K1 Ultrasonidos en medicina
AB Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness and echo-intensity and its possible relationship with functional and patient reported-outcomes (PRO) in MBC patients after an exercise intervention. A prospective study was conducted in 2019. A 12-week exercise program was performed, including aerobic exercise and strength training. Measurements were made at baseline and after intervention. Thickness and echo-intensity were obtained from the quadriceps and biceps brachii and brachialis (BB). Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means before and after the intervention (p = 0.05; 95% CI). Data from 13 MBC patients showed that some US muscle variables had significant differences after intervention. Best correlations were found between the quality of life questionnaire (QLQ-BR23) PRO and variables from BB muscle thickness in contraction (r = 0.61, p < 0.01), and Non-contraction (r = 0.55, p < 0.01). BB Muscle Non-contraction Thickness also explained 70% of QLQ-BR23 variance. In conclusion, muscle architecture biomarkers showed great responsiveness and are correlated with PRO after an exercise intervention in MBC patients.
PB Sci Rep
YR 2021
FD 2021-04-23
LK https://hdl.handle.net/10630/35754
UL https://hdl.handle.net/10630/35754
LA eng
NO Escriche-Escuder, A., Trinidad-Fernández, M., Pajares, B. et al. Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention. Sci Rep 11, 8858 (2021). https://doi.org/10.1038/s41598-021-88375-5
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026