RT Journal Article
T1 Microbiome alterations and Alzheimer's Disease: modeling strategies with transgenic mice.
A1 López-Villodres, Juan Antonio
A1 Escamilla-Sánchez, Alejandro
A1 Mercado-Sáenz, Silvia
A1 Alba-Tercedor, Carmen
A1 Rodríguez-Pérez, Luis Manuel
A1 Arranz-Salas, Isabel María
A1 Sánchez-Varo, Raquel María
A1 Bermúdez-Flores, Diego Teófilo
K1 Alzheimer, Enfermedad de - Modelos animales
AB In the last decade, the role of the microbiota-gut-brain axis has been gaining momentum in the context of many neurodegenerative and metabolic disorders, including Alzheimer's disease (AD) and diabetes, respectively. Notably, a balanced gut microbiota contributes to the epithelial intestinal barrier maintenance, modulates the host immune system, and releases neurotransmitters and/or neuroprotective short-chain fatty acids. However, dysbiosis may provoke immune dysregulation, impacting neuroinflammation through peripheral-central immune communication. Moreover, lipopolysaccharide or detrimental microbial end-products can cross the blood-brain barrier and induce or at least potentiate the neuropathological progression of AD. Thus, after repeated failure to find a cure for this dementia, a necessary paradigmatic shift towards considering AD as a systemic disorder has occurred. Here, we present an overview of the use of germ-free and/or transgenic animal models as valid tools to unravel the connection between dysbiosis, metabolic diseases, and AD, and to investigate novel therapeutical targets. Given the high impact of dietary habits, not only on the microbiota but also on other well-established AD risk factors such as diabetes or obesity, consistent changes of lifestyle along with microbiome-based therapies should be considered as complementary approaches.
PB MDPI
YR 2023
FD 2023-06-27
LK https://hdl.handle.net/10630/28548
UL https://hdl.handle.net/10630/28548
LA eng
NO López-Villodres JA, Escamilla A, Mercado-Sáenz S, Alba-Tercedor C, Rodriguez-Perez LM, Arranz-Salas I, Sanchez-Varo R, Bermúdez D. Microbiome Alterations and Alzheimer's Disease: Modeling Strategies with Transgenic Mice. Biomedicines. 2023 Jun 27;11(7):1846. doi: 10.3390/biomedicines11071846. PMID: 37509487; PMCID: PMC10377071.
NO Partial funding for open access charge: Universidad de Málaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026