RT Journal Article
T1 Analytical methodologies for the determination of cisplatin
A1 Espinosa-Bosch, Maria
A1 Ruiz-Sánchez, Antonio Jesús
A1 Sánchez-Rojas, María Fuensanta
A1 Bosch-Ojeda, Catalina
K1 Cáncer - Tratamiento
AB cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m2 (21 days).A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples.
PB ScienceDirect
YR 2008
FD 2008-07-15
LK https://hdl.handle.net/10630/33368
UL https://hdl.handle.net/10630/33368
LA eng
NO M. Espinosa Bosch, A.J. Ruiz Sánchez, F. Sánchez Rojas, C. Bosch Ojeda, Analytical methodologies for the determination of cisplatin, Journal of Pharmaceutical and Biomedical Analysis, Volume 47, Issue 3, 2008, Pages 451-459, ISSN 0731-7085, https://doi.org/10.1016/j.jpba.2008.01.047.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026