RT Journal Article
T1 Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome
A1 Carrion, Víctor J
A1 Perez-Jaramillo, Juan E
A1 Cordovez, Viviane
A1 Tracanna, Vittorio
A1 De Hollander, Mattias
A1 Ruiz-Buck, Daniel
A1 Mendes, Lucas W
A1 Van Ljcken, Wilfred F.J.
A1 Gomez-Exposito, Ruth
A1 S. Elsayed, Somayah
A1 Mohanraju, Prarthana
A1 Arifah, Adini
A1 Van der Oost, John
A1 Paulson, Joseph N.
A1 Mendes, Rodrigo
A1 Van Wezel, Gilles P
A1 Medema, Marnix
A1 Raaijmakers, Jos M
K1 Plantas - Microbiología
AB Microorganisms living inside plants can promote plant growth and health, but their genomic and functional diversity remain largely elusive. Here, metagenomics and network inference show that fungal infection of plant roots enriched for Chitinophagaceae and Flavobacteriaceae in the root endosphere and for chitinase genes and various unknown biosynthetic gene clusters encoding the production of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). After strain-level genome reconstruction, a consortium of Chitinophaga and Flavobacterium was designed that consistently suppressed fungal root disease. Site-directed mutagenesis then revealed that a previously unidentified NRPS-PKS gene cluster from Flavobacterium was essential for disease suppression by the endophytic consortium. Our results highlight that endophytic root microbiomes harbor a wealth of as yet unknown functional traits that, in concert, can protect the plant inside out
PB Science
YR 2019
FD 2019-11-01
LK https://hdl.handle.net/10630/34335
UL https://hdl.handle.net/10630/34335
LA eng
NO Víctor J. Carrión et al.   , Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome.Science366,606-612(2019).DOI:10.1126/science.aaw9285
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026