RT Conference Proceedings
T1 Unravelling the mechanisms regulating embryonic epicardial cell proliferation.
A1 Marín-Sedeño, Ernesto
A1 Díaz del Moral, Sandra
A1 Sánchez-Mata, Alicia
A1 Díaz-Martínez, Luis
A1 Lescroart, Fabienne
A1 Ruiz-Villalba, Adrián
A1 Pérez-Pomares, José María
K1 Células - Proliferación
K1 Células cardiacas
K1 Corazón
AB Epicardial development is a highly complex process that relies on the precise coordination of cell proliferation and differentiation. The epicardium originates from an extracardiac cluster of cells, the proepicardium, which initially migrates to the myocardium and then massively expands to form the epicardial epithelial layer. Finally, some epicardial epithelial cells transform into mesenchymal cells via Epithelial-to-Mesenchymal Transition (EMT), and progressively invade the myocardial walls. The regulatory signals that govern epicardial cell proliferation remain largely unknown. To unveil the molecular signals involved in controlling epicardial cell proliferation, we examined the proliferation status of epicardial cells at different embryonic stages, and performed an RNA-seq analysis to identify candidate signalling pathways operating within the proepicardium. Then, we conducted in vivo and in vitro research to carefully dissect epicardial proliferation. Our results show that both canonical and non-canonical Wnt signals are involved in the regulation of epicardial proliferation during embryonic development.
YR 2023
FD 2023
LK https://hdl.handle.net/10630/27981
UL https://hdl.handle.net/10630/27981
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.FPU19/05219Ministerio de Ciencia: PID2021-122626-OB-100 y JIN2020-119430RJ-100
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 feb 2026