RT Journal Article
T1 Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
A1 Sampedro-Piquero, Patricia
A1 Ladrón de Guevara-Miranda, David
A1 Pavón-Morón, Francisco Javier
A1 Serrano, Antonia
A1 Suárez-Pérez, Juan
A1 Rodriguez-de-Fonseca, Fernando
A1 Santín-Núñez, Luis Javier
A1 Castilla-Ortega, María Estela
K1 Neuroplasticidad
AB Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead to cognitive deficits that coexist with other addiction symptoms and predict a worse treatment outcome. New learning experiences that are not motivated by drugs may improve both cognitive deficits and drug-induced symptoms by promoting adaptive neuroplastic changes that could alleviate or reverse those involved in addiction. The present review will focus on whether potentiating healthy cognitive function, either by formal cognitive training or non-drug related environmental experiences, could exert beneficial effects in the therapeutics of addiction. Although additional studies are needed, the available clinical and preclinical evidence suggests that cognitive stimulation may provide a valuable adjuvant intervention in drug addiction.
PB Elsevier
YR 2019
FD 2019
LK https://hdl.handle.net/10630/23840
UL https://hdl.handle.net/10630/23840
LA eng
NO Sampedro-Piquero, P., Ladrón de Guevara-Miranda, D., Pavón, F. J., Serrano, A., Suárez, J., Rodríguez de Fonseca, F., Santín, L. J., & Castilla-Ortega, E. (2019). Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation. Neuroscience & Biobehavioral Reviews, 106, 23–48. https://doi.org/10.1016/J.NEUBIOREV.2018.11.015
NO Author manuscript
NO This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (Agencia Estatal de Investigación) co-founded by the European Research Development Fund-AEI/FEDER, UE- (PSI2015-73156-JIN to E.C.O.; PSI2017-82604R to L.J.S.), Red deTrastornos Adictivos (RD16/0017/0001 to F.R.F.), Plan Nacional sobre Drogas, Ministerio de Sanidad, Servicios Sociales e Igualdad (PNSD2015/047 to J.S.) and the University of Málaga (Plan Propio 2017 – ‘Ayudas para proyectos dirigidos por jóvenes investigadores’, PPIT.UMA.B1.2017/38 to P.S.P).Author P.S.P. holds a ‘Juan de la Cierva-formación’ grant from the Spanish Ministry of Economy, Industry and Competitiveness (code: FJCI-2015-23925). Author D.L.G.M. holds a ‘FPU’ grant from the Spanish Ministry of Education, Culture and Sports (code: FPU13/04819). Authors J.S., A.S. and F.J.P. hold ‘Miguel Servet’ grants (codes: CPII17/00024, CP14/00173 and CP14/00212, respectively) from the National System of Health-Instituto de Salud Carlos- III co-funded by FEDER, UE. Author E.C.O. holds a ‘Jóvenes Investigadores’ grant (code: PSI2015-73156-JIN) from the Spanish Ministry of Economy and Competitiveness (Agencia Estatal de Investigación) co-funded by FEDER, UE.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026