RT Dissertation/Thesis
T1 Silicon Photonics Mach-Zehnder Biosensor with Coherent Detection for Point-of-Care Devices
A1 Leuermann, Jonas
K1 Interferómetros laser
AB Integrated photonic biosensors are a highly promising technology platform for biochemical diagnostics. In general, they have demonstrated impressively low detection limits and can offer highly multiplexed operations in real time. Ring-resonator-based photonic biosensors have been shown to be a practical solution for lab-on-chip solutions and first commercial products are already available. However, they mostly require an expensive high-quality laser for accurate operation. In recent years, interferometer-based photonic sensors have demonstrated even lower detection limits as well as multiplexation capabilities and are candidates for future point-of-care devices for primary care, directly at the patient site. Point-of-care solutions require a portable and inexpensive device. The read-out, i.e. optical source, detection scheme, and signal processing, typically make up a significant part of an integrated photonic biosensor system’s price. Ring-resonator-based systems often need a tunable narrow-linewidth laser as optical source to extract the resonance wavelength, whereas interferometers just need a fixed wavelength source to accurately extract the phase shift, but can suffer from sensitivity fading and ambiguity. In this thesis we investigate a coherently read symmetric Mach-Zehnder interferometer that overcomes these drawbacks and show that it is an attractive solution for point-of-care devices for several reasons.
PB UMA Editorial
YR 2021
FD 2021-06-16
LK https://hdl.handle.net/10630/22473
UL https://hdl.handle.net/10630/22473
LA eng
NO One important aspect is its immunity to laser phase noise and relative intensity noise. That means that inexpensive fixed wavelength Fabry-Perot lasers can be used with this type of sensor. This reduces the cost of the light source tremendously. Within this work it was demonstrated that it can reach cutting-edge state-of-the-art detection limits in typical bulk sensing and biosensing (with C-reactive protein) performance verification. Finally, targeting a real application scenario, the specific detection of IgG and IgE amoxicillin antibodies was demonstrated applying amoxicillin haptenised PAMAM G2 dendrimers on the sensing area.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026