RT Conference Proceedings
T1 Use of human bone marrow mesenchymal stem cell exosomes for ependymal repair and edema reduction in posthemorrhagic hydrocephalus treatment
A1 Lopez-de-San-Sebastian, Javier
A1 Rodríguez-Pérez, Luis Manuel
A1 Anguita-Guardia, Alba
A1 Jiménez-Lara, Antonio Jesús
A1 Páez-González, Patricia
K1 Líquido cefalorraquídeo - Congresos
K1 Epéndimo - Congresos
AB Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) often lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which acts as a functional and physical barrier between the cerebrospinal fluid and the brain tissue. As a consequence, cerebrospinal fluid circulation and physiology are severely affected; and thus, makes ependyma a chiefly important target when it comes to designing PHH treatments. Bone marrow-derived mesenchymal stem cells (MSCs) are extremely effective anti-inflammatory agents which have already shown positive results in PHH treatment. However, there is no current therapy to recover the ependyma in humans.
YR 2025
FD 2025-09-03
LK https://hdl.handle.net/10630/45476
UL https://hdl.handle.net/10630/45476
LA eng
NO Junta de Andalucía
NO Unión Europea
NO Ministerio de Ciencia, Innovación y Universidades
NO Instituto de Salud Carlos III
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026