RT Journal Article T1 Affective dysregulation, familial psychopathology, and suicidal behavior in transgender individuals: A structural equation model A1 Sánchez-Álvarez, Nicolás K1 Personas transgénero K1 Suicidio K1 Estadística K1 Agresividad (Psicología) K1 Trastornos afectivos AB Background: Transgender individuals present disproportionately high rates of suicidal behavior, yet little isknown about the affective and familial mechanisms that explain this vulnerability. This study examined anexplanatory model of suicidal behavior grounded in affective dysregulation, impulsive aggression, and familialpsychopathology.Methods: A clinical sample of 506 transgender individuals attending a gender identity unit in Spain completedstructured assessments of mood disorders, impulsive aggression, exposure to violence, childhood abuse, andsuicidal behaviors. Structural equation modeling (SEM) using maximum likelihood estimation was applied to testdirect and indirect pathways linking familial and affective variables to suicide attempts.Results: The final model demonstrated excellent fit (χ2/df = 1.692, GFI = 0.955, IFI = 0.956, RMSEA = 0.037)and explained 48% of the variance in suicide attempts. Affective dysregulation (β = 0.520, p < .001), impulsiveaggression (β = 0.173, p = .015), and environmental adversity (β = 0.420, p < .001) were significant predictorsof suicidal behavior. Parental mood disorders exerted indirect effects on suicide attempts through their influenceon offspring mood disturbances.Limitations: The cross-sectional design precludes causal inference. Mood disorder diagnoses relied on clinicalinterviews rather than standardized diagnostic instruments. The wide age range may limit generalizability toadolescent-specific samples.Conclusions: Findings indicate that suicidal behavior in transgender individuals arises from interrelated affective,familial, and environmental mechanisms. Early detection of mood disturbances, assessment of impulsiveaggression, and family-based interventions may help reduce suicide vulnerability in this population. PB Elsevier YR 2026 FD 2026-04-13 LK https://hdl.handle.net/10630/46410 UL https://hdl.handle.net/10630/46410 LA eng NO Nicolás Sánchez-Álvarez, Affective dysregulation, familial psychopathology, and suicidal behavior in transgender individuals: A structural equation model, Journal of Affective Disorders, Volume 407, 2026, 121793, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2026.121793 NO Funding for open access charge: Universidad de Málaga/CBUA DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 4 may 2026