RT Journal Article
T1 Modeling drug-induced liver injury: current status and future prospects.
A1 Di Zeo-Sánchez, Daniel Enrique
A1 Segovia-Zafra, Antonio
A1 Matilla-Cabello, Gonzalo
A1 Pinazo-Bandera, José M.
A1 Andrade-Bellido, Raúl Jesús
A1 Lucena-González, María Isabel
A1 Villanueva-Paz, Marina
K1 Hepatotoxicidad - Aspectos genéticos
K1 Estrés oxidativo
K1 Hígado - Heridas y lesiones
AB IntroductionIdiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable multifactorial condition. At present, validated preclinical models for the prediction of the hepatotoxic potential of a given drug are scarce.Areas coveredThis review intends to sum up the current knowledge about in vitro (including hepatocyte 2D cultures, cocultures with non-parenchymal cells, 3D configurations and non-typical closer to reality in vitro models), in vivo (covering models for immunological and oxidative stress features, humanized mouse-based and non-rodent models) and in silico approaches for iDILI modeling, highlighting the recent advances in each topic.Expert opinionThe future strategy for iDILI modeling should be patient-centered. Future animal and cell-based models, with more predictive value, will be easier to design by using a more translational approach based on mechanisms demonstrated in humans. Genetic and epigenetic information gathered from iDILI patients, together with data from in vitro and in vivo studies, could be used to develop sophisticated predictive in silico models to find compounds with iDILI potential. Collecting genetic, metabolic, and biomarker data from patient cohorts might be another option to create a ‘fingerprint’ characteristic of people at risk, allowing for the development of new, mechanistic strategies to enhance iDILI in vitro evaluation.
PB Taylor & Francis
YR 2022
FD 2022-09-16
LK https://hdl.handle.net/10630/38162
UL https://hdl.handle.net/10630/38162
LA eng
NO Daniel E. Di Zeo-Sánchez, Antonio Segovia-Zafra, Gonzalo Matilla-Cabello, José M. Pinazo-Bandera, Raúl J. Andrade, M. Isabel Lucena & Marina Villanueva-Paz (2022) Modeling drug-induced liver injury: current status and future prospects, Expert Opinion on Drug Metabolism & Toxicology, 18:9, 555-573, DOI: 10.1080/17425255.2022.2122810
NO This work was supported by grants of Instituto de Salud Carlos III, cofounded by European Union (contract numbers: PI21/01248, PI19-00883, PT 20/00127, UMA18-FEDERJA-194, PY18-3364) and grants of Consejería de Salud de Andalucía cofounded by FEDER (contract number: PEMP-0127-2020).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 16 abr 2026