RT Journal Article
T1 Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma
A1 Becerra-Rodríguez, María de los Ángeles
A1 González-Muñoz, María Elena
A1 Moore, Tom
K1 Neuroglia
K1 Ingeniería genética
K1 Gliomas
AB The segmentally duplicated Pregnancy-specific glycoprotein (PSG) locus on chromosome 19q13 may be one of the most rapidly evolving in the human genome. It comprises ten coding genes (PSG1-9, 11) and one predominantly non-coding gene (PSG10) that are expressed in the placenta and gut, in addition to several poorly characterized long non-coding RNAs. We report that long non-coding RNA PSG8-AS1 has an oligodendrocyte-specific expression pattern and is co-expressed with genes encoding key myelin constituents. PSG8-AS1 exhibits two peaks of expression during human brain development coinciding with the most active periods of oligodendrogenesis and myelination. PSG8-AS1 orthologs were found in the genomes of several primates but significant expression was found only in the human, suggesting a recent evolutionary origin of its proposed role in myelination. Additionally, because co-deletion of chromosomes 1p/19q is a genomic marker of oligodendroglioma, expression of PSG8-AS1 was examined in these tumors. PSG8-AS1 may be a promising diagnostic biomarker for glioma, with prognostic value in oligodendroglioma.
PB Elsevier
YR 2024
FD 2024-06-10
LK https://hdl.handle.net/10630/38834
UL https://hdl.handle.net/10630/38834
LA eng
NO Maria de los Angeles Becerra Rodriguez, Elena Gonzalez Muñoz, Tom Moore, Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma, Non-coding RNA Research, Volume 9, Issue 4, 2024, Pages 1061-1068, ISSN 2468-0540, https://doi.org/10.1016/j.ncrna.2024.06.008.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026