RT Journal Article
T1 Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study
A1 Barbancho-Fernández, Miguel Ángel
A1 Berthier-Torres, Marcelo Luis
A1 Navas-Sánchez, Patricia
A1 Dávila-Arias, María Guadalupe
A1 Green-Heredia, Cristina
A1 García-Alberca, J.M.
A1 Ruiz-Cruces, Rafael
A1 López-González, Manuel Víctor
A1 Dawid-Milner, Marc Stefan
A1 Pulvermüller, Friedemann
A1 Lara-Muñoz, José Pablo
K1 Afasia - Tratamiento
K1 Cerebro - Hemorragia -  Complicaciones y secuelas - Tratamiento
AB Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0–16), followed by drug treatment combined with CIAT (weeks 16–18), and then memantine/placebo alone (weeks 18–20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16–18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18–20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.
PB Elsevier
YR 2015
FD 2015
LK https://hdl.handle.net/10630/29444
UL https://hdl.handle.net/10630/29444
LA eng
NO Miguel A. Barbancho, Marcelo L. Berthier, Patricia Navas-Sánchez, Guadalupe Dávila, Cristina Green-Heredia, José M. García-Alberca, Rafael Ruiz-Cruces, Manuel V. López-González, Marc S. Dawid-Milner, Friedemann Pulvermüller, J. Pablo Lara, Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study, Brain and Language, Volumes 145–146, 2015, Pages 1-10, ISSN 0093-934X, https://doi.org/10.1016/j.bandl.2015.04.003.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026