RT Journal Article T1 Exploring the interplay of frailty, physical function, physical activity, nutritional status, and their association with quality of life and depressive symptoms in older adults with the frailty phenotype A1 Casals, Cristina A1 Corral-Pérez, Juan A1 Ávila-Cabeza-de-Vaca, Laura A1 González-Mariscal, Andrea A1 Carrión-Velasco, Yolanda A1 Rodríguez-Martínez, María del Carmen A1 Jiménez-Cebrián, Ana María A1 Vázquez-Sánchez, María Ángeles K1 Depresión mental - Tratamiento AB Objective: This study aimed to explore the interplay between frailty, physicalfunction, physical activity, nutritional status, and their impact on the quality of lifeand depressive status in older adults with frailty.Methods: A cross‐sectional study involving 235 pre‐frail/frail older adults residingin Spanish communities was conducted. Frailty was assessed using Fried's criteria,physical function was evaluated using the Short Physical Performance Battery, andphysical activity levels were measured via wrist‐worn accelerometers. Nutritionalstatus was determined using the Mini‐Nutritional Assessment alongside anthropometricmeasurements. Quality of life was gauged using the EuroQoL 5‐Dimension 5‐Level, while depressive status was assessed using the Yesavage 15‐item GeriatricDepression Scale. Multivariate linear regression and logistic regression analyseswere employed to elucidate the associations of these factors with quality of life anddepression.Results: Our findings revealed significant correlations between various factors andquality of life. Notably, reported fatigue (β = −0.276, p = 0.002), performance in the4‐m gait test (β = −0.242, p = 0.001), the score on the short version of the Mini‐Nutritional Assessment (β = 0.312, p = 0.002), and engagement in light physicalactivity (β = 0.180, p = 0.023) were all found to be associated with quality of life. Interms of depressive symptoms, the Mini‐Nutritional Assessment score emerged as aprotective factor (Odds ratio, OR: 0.812, p < 0.001), as did participation in moderatephysical activity (OR: 0.988, p = 0.028). Conversely, fatigue (OR: 3.277, p = 0.003)and a slow gait speed (OR: 1.136, p = 0.045) were identified as risk factors fordepressive symptoms PB Wiley Online Library YR 2024 FD 2024-03 LK https://hdl.handle.net/10630/35674 UL https://hdl.handle.net/10630/35674 LA eng NO Casals C, Corral-Pérez J, Ávila-Cabeza-de-Vaca L, et al. Exploring the interplay of frailty, physical function, physical activity, nutritional status, and their association with quality of life and depressive symptoms in older adults with the frailty phenotype. Int J Geriatr Psychiatry. 2024;e6078. https://doi.org/10.1002/gps.6078 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 19 ene 2026