RT Journal Article
T1 Traumatic brain injury induces tau aggregation and spreading.
A1 Edwards, George
A1 Zhao, Jing
A1 Dash, Pramod
A1 Soto, Claudio
A1 Moreno-González, Inés
K1 Cerebro - Heridas y lesiones
K1 Tubulinas
AB The misfolding and aggregation of tau protein into neurofibrillary tangles is the main underlying hallmark of tauopathies. Most tauopathies have a sporadic origin and can be associated with multiple risk factors. Traumatic brain injury (TBI) has been suggested as a risk factor for tauopathies by triggering disease onset and facilitating its progression. Several studies indicate that TBI seems to be a risk factor to development of Alzheimer disease and chronic traumatic encephalopathy, because there is a relationship of TBI severity and propensity to development of these illnesses. In this study, we evaluated whether moderate to severe TBI can trigger the initial formation of pathological tau that would induce the development of the pathology throughout the brain. To this end, we subjected tau transgenic mice to TBI and assessed tau phosphorylation and aggregation pattern to create a spatial heat map of tau deposition and spreading in the brain. Our results suggest that brain injured tau transgenic mice have an accelerated tau pathology in different brain regions that increases over time compared with sham mice. The appearance of pathological tau occurs in regions distant to the injury area that are connected synaptically, suggesting dissemination of tau aggregates. Overall, this work posits TBI as a risk factor for tauopathies through the induction of tau hyperphosphorylation and aggregation.
PB Mary Ann Liebert Inc.
YR 2020
FD 2020
LK https://hdl.handle.net/10630/37112
UL https://hdl.handle.net/10630/37112
LA eng
NO Edwards, G., Zhao, J., Dash, P. K., Soto, C., & Moreno-Gonzalez, I. (2020). Traumatic brain injury induces tau aggregation and spreading. Journal of Neurotrauma, 37(1), 80-92.
NO This work was partially funded by Department of Defense Peer Reviewed Alzheimer’s Research Program Convergence Science Research Award grant AZ160106 to IMG and AZ160082 to CS; Alzheimer’s Association New Investigator Research Grant NIRG-394284 to IMG; The University of Texas System-Neuroscience and Neurotechnology Research Institute UTBrain seed grant program to CS, and NIH-NINDS grant F31NS103499 to GE3.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026