RT Journal Article
T1 Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis.
A1 Rodríguez González Cortes, Arthur
A1 Sánchez-Siles, Juan Manuel
A1 Ackerman, Jerome L
A1 González-Quevedo, David
A1 Garcia, Angel
A1 Yaghoubi, Farid
A1 Abdallah, Mohamed-Nur
A1 Eimar, Hazem
A1 Alsheghri, Ammar
A1 Laurenti, Marco
A1 Guerado-Parra, Enrique
A1 García-de-Quevedo-Puerta, David
A1 Tamimi, Faleh
K1 Tomografía
K1 Imágenes por resonancia magnética
K1 Fémures - fracturas
AB Purpose: The aim of this study was to analyze trabecular bone architecture, and its crystal and organic composition in humans, by comparing samples taken from patients who had a hip fracture (HF) and individuals with hip osteoarthritis (HOA).Methods: The study included 31 HF patients and 42 cases of HOA who underwent joint replacement surgery between 1/1/2013 and 31/12/2013. Trabecular bone samples were collected from the femoral heads and analyzed using a dual-energy X-ray absorptiometry, micro-CT, and solid-state high-resolution magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectroscopy.Results: No differences in proton or phosphorus concentration were found between the two groups using 1H single pulse, 31P single pulse, 31P single pulse with proton decoupling NMR spectroscopy, in hydroxyapatite (HA) c-axis or a-axis crystal length. Bone volume fraction (BV/TV), trabecular number (Tb.N), and bone mineral density (BMD) were higher in the HO group than in the HF group [28.6% ± 10.5 vs 20.3% ± 6.6 (p = 0.026); 2.58 mm-1 ± 1.57 vs 1.5 mm-1 ± 0.79 (p = 0.005); and 0.39 g/cm2 ± 0.10 vs. 0.28 g/cm2 ± 0.05 (p = 0.002), respectively]. The trabecular separation (Tp.Sp) was lower in the HO group 0.42 mm ± 0.23 compared with the HF group 0.58 mm ± 0.27 (p = 0.036). In the HO group, BMD was correlated with BV/TV (r = 0.704, p < 0.001), BMC (r = 0.853, p < 0.001), Tb.N (r = 0.653, p < 0.001), Tb.Sp (-0.561, p < 0.001) and 1H concentration (-0.580, p < 0.001) in the HO group. BMD was not correlated with BV/TV, Tb.Sp, Tb.Th, Tb.N, Tb.PF, 1H concentration or HA crystal size in the HF group.Conclusions: Patients with HO who did not sustain previous hip fractures had a higher femoral head BMD, BV/TV, and Tb.N than HF patients. In HO patients, BMD was positively correlated with the BV/TV and Tb.N and negatively correlated with the femoral head organic content and trabecular separation.
PB Elsevier
YR 2020
FD 2020-08-12
LK https://hdl.handle.net/10630/36896
UL https://hdl.handle.net/10630/36896
LA eng
NO Tamimi I, Cortes ARG, Sánchez-Siles JM, Ackerman JL, González-Quevedo D, García Á, Yaghoubi F, Abdallah MN, Eimar H, Alsheghri A, Laurenti M, Al-Subaei A, Guerado E, García-de-Quevedo D, Tamimi F. Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis. Bone. 2020 Nov;140:115558. doi: 10.1016/j.bone.2020.115558. Epub 2020 Jul 27. PMID: 32730941.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/16737
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 10 abr 2026