RT Conference Proceedings
T1 Cognitive decline and tau-associated pathology worsen after late-life depression in P301S mice.
A1 Vegas-Gómez, Laura
A1 Gutiérrez-Sastre, Cristina
A1 Arredondo-Alcalá, María Ángeles
A1 Gutiérrez-Pérez, Antonia
A1 Moreno-González, Inés
K1 Alzheimer, Enfermedad de
K1 Depresión mental - Modelos animales
AB Recent studies suggest that depression may be a crucial risk factor for the development ofcognitive impairment and Alzheimer's disease (AD). In fact, there is a strong associationbetween late-life depression and AD. The age of AD onset has been shown to be accelerated inpatients with mild cognitive impairment (MCI) with a history of depression, and women appear tobe particularly more vulnerable to this condition. In addition, individuals with MCI who presentdepressive symptoms have an elevated burden of amyloid-beta, the main toxic proteinassociated with AD pathology, and a higher risk of developing AD compared to non-depressedMCI patients. Although it has been described that some transgenic models of AD can developsigns similar to depression in advanced stages, the induction of AD pathology due to adepressive process has not been studied under experimental conditions to emulate late-lifedepression as a risk factor for dementia. The objective of this study is to determine, by inducingunpredictable mild chronic stress (CUMS) in tau transgenic P301S mice, whether depression isa cause, rather than a consequence, of tau-associated pathology. The results of our studyindicate that the induction of CUMS in transgenic animals accelerates tau pathology, synapticimpairment, elevates neuroinflammation, and triggers GABAergic alterations, in addition toworsen clinical signs. The findings generated in this project could provide solid evidence ofdepression as a risk factor for AD and other tauopathies.
YR 2024
FD 2024
LK https://hdl.handle.net/10630/31914
UL https://hdl.handle.net/10630/31914
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026