RT Journal Article
T1 Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus
A1 Sánchez-Quintero, María José
A1 Delgado, Josué
A1 Medina-Vera, Dina
A1 Becerra-Muñoz, Víctor Manuel
A1 Queipo-Ortuño, María Isabel
A1 Estévez, Mario
A1 Plaza-Andrades, Isaac
A1 Rodríguez Capitán, Jorge
A1 Sánchez, Pedro L.
A1 Crespo-Leiro, María G.
A1 Jiménez-Navarro, Manuel Francisco
A1 Pavón-Morón, Francisco Javier
K1 Compuestos carbonílicos
AB Ischemic heart disease (IHD) and type-2 diabetes mellitus (T2DM) remain major health problems worldwide and commonly coexist in individuals. Gut microbial metabolites, such as trimethylamine N-oxide (TMAO) and short-chain fatty acids (SCFAs), have been linked to cardiovascular and metabolic diseases. Previous studies have reported dysbiosis in the gut microbiota of these patients and the prebiotic effects of some components of the Mediterranean diet. Essential oil emulsions of savory (Satureja hortensis), parsley (Petroselinum crispum) and rosemary (Rosmarinus officinalis) were assessed as nutraceuticals and prebiotics in IHD and T2DM. Humanized mice harboring gut microbiota derived from that of patients with IHD and T2DM were supplemented with L-carnitine and orally treated with essential oil emulsions for 40 days. We assessed the effects on gut microbiota composition and abundance, microbial metabolites and plasma markers of cardiovascular disease, inflammation and oxidative stress. Our results showed that essential oil emulsions in mice supplemented with L-carnitine have prebiotic effects on beneficial commensal bacteria, mainly Lactobacillus genus. There was a decrease in plasma TMAO and an increase in fecal SCFAs levels in mice treated with parsley and rosemary essential oils. Thrombomodulin levels were increased in mice treated with savory and parsley essential oils. While mice treated with parsley and rosemary essential oils showed a decrease in plasma cytokines (INFɣ, TNFα, IL-12p70 and IL-22); savory essential oil was associated with increased levels of chemokines (CXCL1, CCL2 and CCL11). (...)
PB IOAP-MPDI
YR 2022
FD 2022-11-03
LK https://hdl.handle.net/10630/25880
UL https://hdl.handle.net/10630/25880
LA eng
NO Sánchez-Quintero MJ, Delgado J, Medina-Vera D, Becerra-Muñoz VM, Queipo-Ortuño MI, Estévez M, Plaza-Andrades I, Rodríguez-Capitán J, Sánchez PL, Crespo-Leiro MG, Jiménez-Navarro MF, Pavón-Morón FJ. Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus. Nutrients. 2022; 14(21):4650. https://doi.org/10.3390/nu14214650
NO This work was supported by the following projects and programs: Research project (PI-0170-2018) funded by Consejería de Salud y Familias-Junta de Andalucía and the European Regional Development Funds/European Social Fund (ERDF/ESF); Projects funded by the Sociedad Española de Cardiología and Fundación Andaluza de Cardiología; Plataforma ISCIII de Biobancos y Biomodelos de IBIMA (PT20/00101) funded by Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación-Gobierno de España; CIBERCV (CB16/11/00360) funded by Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación-Gobierno de España and ERDF/ESF. M.J.S.Q. holds a Senior Postdoc Researcher contract (RH-0078-2021) funded by Consejería de Salud y Familias-Junta de Andalucía and ERDF/ESF; F.J.P.M. holds a Miguel Servet II research contract (CPII19/00022) and D.M.-V. holds a PFIS contract (FI20/00227) funded by Instituto de Salud Carlos III and ERDF/ESF. J.D. was recipient of mobility grants (MOV19-003) funded by IBIMA and CIBERCV. This study has received support from the Cátedra de Terapias Avanzadas en Patología Cardiovascular (CIF Q-2918001-E), Universidad de Málaga.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026