RT Journal Article
T1 Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats.
A1 Mela-Rivas, Virginia
A1 Hernández, Oskarina
A1 Hunsche, Caroline
A1 Díaz, Francisca
A1 Chowen, Julie Ann
A1 De la Fuente, Mónica
K1 Inflamación (Patología)
K1 Citoquinas
K1 Inmunidad celular
K1 Antioxidantes
K1 Leptina - Antagonistas
K1 Modelos animales en investigación
AB The importance of the neonatal leptin surge in rodents in neurodevelopmental processes has aroused curiosity in its implication in other physiological systems. Given the role of leptin in neuro-immune interactions, we hypothesized that the neonatal leptin surge could have an effect on the oxidative and inflammatory stress situations of both systems. We blocked the neonatal leptin surge by a leptin antagonist and measured several parameters of oxidative and inflammatory stress in the spleen, hypothalamus and adipose tissue of peripubertal/adolescent rats. The treated rats showed lower activity of several antioxidant enzymes in the spleen and their leukocytes released lower levels of mitogen-stimulated IL-10 and IL-13 and higher levels of TNF-alpha. In conclusion, the neonatal leptin surge may have a key role in the establishment of adequate redox and inflammatory states in the immune system, which is important for the generation of adequate immune responses and to obtain and maintain good health.
PB Elsevier
YR 2017
FD 2017-10-15
LK https://hdl.handle.net/10630/40709
UL https://hdl.handle.net/10630/40709
LA eng
NO Mela V, Hernandez O, Hunsche C, Diaz F, Chowen JA, De la Fuente M. Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats. Mol Cell Endocrinol. 2017 Oct 15;454:125-134. doi: 10.1016/j.mce.2017.06.018. Epub 2017 Jun 19. PMID: 28641938.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026