RT Journal Article
T1 Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients.
A1 González-Billalabeitia, Enrique
A1 Castellano, Daniel
A1 Sobrevilla, Nora
A1 Guma, Josep
A1 Hervás, David
A1 Luengo, María I.
A1 Aparicio, Jorge
A1 Sánchez-Muñoz, Alfonso
A1 Mellado, Begoña
A1 Sáenz, Alberto
A1 Valverde, Claudia
A1 Fernández, Antonio
A1 Margelí, Mireia
A1 Durán, Ignacio
A1 Fernández, Sara
A1 Sastre, Javier
A1 Ros, Silverio
A1 Maroto, Pablo
A1 Manneh, Ray
A1 Cerezuela, Pablo
A1 Carmona-Bayonas, Alberto
A1 Ayala de la Peña, Francisco
A1 Aguilar, José Luis
A1 Rivera, Samuel
A1 García del Muro, Xavier
A1 Germá-Lluch, José Ramón
K1 Células germinales - Cáncer
K1 Tromboembolismo
K1 Cáncer - Pronóstico
AB Background: Disseminated germ cell cancers are at high risk of developing thromboembolic complications. We evaluated the prognostic value of venous thromboembolic events (VTE) in disseminated germ cell cancer.Results: The SGCCG registry identified 416 patients from 14 referral institutions. With a median follow-up of 49 months, VTEs were observed in 9% of patients (n = 38). Events occurred at diagnosis, during chemotherapy, and after chemotherapy in 2.6%, 5.0%, and 1.4% of patients, respectively. VTE was associated with shorter progression-free survival (PFS; hazard ratio [HR] = 2.29, 95% confidence interval [CI] = 1.18 to 4.47, P = .02) and overall survival (OS; HR = 5.14, 95% CI = 2.22 to 11.88, P < .001). In multivariable analysis, the effect was consistent in the intermediate-risk group, both for PFS (HR = 9.52 95% CI = 2.48 to 36.58, P < .001) and OS (HR = 12.84, 95% CI = 2.01 to 82.02, P = .007). VTE at diagnosis is also an adverse prognostic variable for progression-free survival (HR = 4.64, 95% CI = 2.04 to 10.54, P < .001) and for overall survival (HR = 6.28, 95% CI = 1.68 to 17.10, P = .01). These results were validated in an independent international cohort that included 241 patients from four hospitals.Conclusions: VTE is an independent adverse prognostic factor in disseminated germ cell cancers, in particular for the intermediate prognostic group of the International Germ Cell Cancer Collaborative Group classification. The presence of VTE at diagnosis has also prognostic significance and should be further explored in future prognostic classifications.
PB Oxford Academic
YR 2017
FD 2017-01-26
LK https://hdl.handle.net/10630/31195
UL https://hdl.handle.net/10630/31195
LA eng
NO Gonzalez-Billalabeitia E, Castellano D, Sobrevilla N, Guma J, Hervas D, Luengo MI, Aparicio J, Sanchez-Muñoz A, Mellado B, Saenz A, Valverde C, Fernandez A, Margeli M, Duran I, Fernandez S, Sastre J, Ros S, Maroto P, Manneh R, Cerezuela P, Carmona-Bayonas A, Ayala de la Peña F, Luis Aguilar J, Rivera S, García Del Muro X, Germà-Lluch JR; Spanish Germ Cell Cancer Group/Grupo Germinal (SGCCG). Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients. J Natl Cancer Inst. 2017 Jan 25;109(4). doi: 10.1093/jnci/djw265. PMID: 28122896.
NO Este artículo ha sido publicado en la revista JNCI J Natl Cancer InstEsta versión tiene Licencia Creative Commons CC-BY-NC-NDPolítica de acceso abierto tomada de: https://academic.oup.com/pages/self_archiving_policy_b
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026