RT Journal Article
T1 Influence of the hydroxytyrosol/triterpenes ratio on the neuroprotective effect of olive oil in an experimental model of diabetes mellitus
A1 De-la-Cruz-Cortés, José Pedro
A1 Repiso, Ignacio
A1 Rodríguez-Pérez, María Dolores
A1 Sánchez-Tévar, Ana María
A1 Ortega-Hombrados, Laura
A1 Martín Aurioles, Esther
A1 Arrebola Ramírez, María Monsalud
A1 Pérez-Burillo, Sergio
A1 Fernández-Prior, María África
A1 González-Correa, José Antonio
K1 Aceite de oliva
AB The aim of the study is to analyse the possible neuroprotective effect of two types of olive oils, one with a high content of alcoholic phenols (POO) and the other with a high content of alcoholic phenols and triterpenes (PTOO), in an experimental model of diabetes mellitus. We also aimed to assess the participation of triterpenes, alone or in association with hydroxytyrosol, in the neuroprotective effect of these olive oils. We administered 0.5 mL/kg/d of both oils to type 1 diabetic animals and performed a hypoxia-reoxygenation model in brain slices. Both oils reduced cell death in this experimental model: 38.3% with POO and 57.2% with PTOO. Both oils reduced brain oxidative stress in this model, with PTOO showing a greater effect than POO in increasing brain antioxidant variables. In in vitro experiments in the hypoxia-reoxygenation model, both hydroxytyrosol and triterpene compounds reduced cell death (IC50 17.7±0.5 µmol/L for triterpenes and 58.7±1.1 µmol/L for hydroxytyrosol. They also showed an antioxidant effect in the experimental model. When associating both types of compounds in proportion to their concentrations in POO and PTOO, a greater neuroprotective and antioxidant effect was quantified, mainly in the inhibition of lipid peroxidation and in the increase of antioxidant variables. It is concluded that the administration of PTOO exerts a greater neuroprotective effect, possibly due to a positive interaction between the content of triterpenes and alcoholic phenols present in olive oils.
PB Elsevier
YR 2026
FD 2026-06
LK https://hdl.handle.net/10630/45720
UL https://hdl.handle.net/10630/45720
LA eng
NO De La Cruz, José Pedro, Repiso, Ignacio, Rodríguez-Pérez, María Dolores, Sánchez-Tévar,Ana María, Ortega-Hombrados, Laura, Martín Aurioles, Esther,  Arrebola Ramírez, María Monsalud, Pérez-Burillo, Sergio, Fernández-Prior, María África,  González-Correa, José Antonio. (2026). Influence of the hydroxytyrosol/triterpenes ratio on the neuroprotective effect of olive oil in an experimental model of diabetes mellitus. The Journal of Nutritional Biochemistry. Vol. 152, junio
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 mar 2026