RT Journal Article
T1 The Role of Astrocytes in Synaptic Dysfunction and Memory Deficits in Alzheimer's Disease
A1 Muñoz de León-López, Cristina Anabel
A1 Navarro-Lobato, Irene
A1 Khan, Zafaruddin
K1 Astrocitos
AB Astrocytes are the most abundant glial cells in the brain. They play critical roles in synapse formation and function, neurotransmitter release and uptake, the production of trophic factors, and energy supply for neuronal survival. In addition to producing proteases for amyloid-β degradation, astrocytes express various receptors, transporters, gliotransmitters,and other molecules that enable them to sense and respond to external signals. They are also implicated in amyloid-β clearance. In Alzheimer’s disease, excessive accumulationof amyloid-β induces the polarization of astrocytes into the A1 phenotype, promoting the release of inflammatory cytokines and mitochondrial reactive oxygen species, leading to alterations in astrocytic functions. Under such conditions, gliotransmitter release, glutamate neurotransmission, AMPA receptor trafficking, and both Hebbian and non-Hebbian formsof synaptic plasticity—biological activities essential for synaptic functions—are compromised. Moreover, astrocytes are essential for learning, memory, and synaptic plasticity, andalterations in their function are associated with memory deficits in Alzheimer’s disease. This review provides an overview of the current understanding of the defects in astrocytesthat lead to altered synaptic functions, neuronal structural plasticity, and memory deficits in Alzheimer’s disease.
PB MDPI
YR 2025
FD 2025-06-20
LK https://hdl.handle.net/10630/45890
UL https://hdl.handle.net/10630/45890
LA eng
NO Muñoz de León-López, C.A.; Navarro-Lobato, I.; Khan, Z.U. The Role of Astrocytes in Synaptic Dysfunction and Memory Deficits in Alzheimer’s Disease. Biomolecules 2025, 15, 910.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 18 mar 2026