RT Journal Article
T1 Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes
A1 Du, Xiaoyong
A1 Cheng-Sánchez, Iván
A1 Nevado, Cristina
K1 Níquel
AB An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C–C and a C–S bond across the π-system, uses a dual nickel/photoredox catalytic system to produce both β-aryl and β-alkenyl sulfones in high yields and with excellent levels of stereocontrol (up to 99:1 er). This protocol exhibits a broad substrate scope and excellent functional group tolerance and its synthetic potential has been demonstrated by successful applications toward pharmacologically relevant molecules. A broad array of control experiments supports the involvement of a secondary alkyl radical intermediate generated through radical addition of a sulfonyl radical to the double bond. Moreover, stoichiometric and cross-over experiments further suggest an underlying Ni(0)/Ni(I)/Ni(III) pathway operative in these transformations.
PB ACS
YR 2023
FD 2023-05-30
LK https://hdl.handle.net/10630/36193
UL https://hdl.handle.net/10630/36193
LA eng
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026