RT Journal Article
T1 Can a minimal replicating construct be identified as the embodiment of cancer?
A1 Solé, Ricard V.
A1 Valverde, Sergi
A1 Rodríguez-Caso, Carlos Francisco
A1 Sardanyés, Josep
K1 Carcinogénesis - Aspectos moleculares
AB Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis involves a loss of key components of the genetic and signalling molecular networks; hence some authors have suggested that this is part of a trend of cancer cells to behave as simple, minimal replicators. In this study, we explore this conjecture and suggest that, in the case of cancer, genomic instability has an upper limit that is associated with a minimal cancer cell network. Such a network would include (for a given microenvironment) the basic molecular components that allow cells to replicate and respond to selective pressures. However, it would also exhibit internal fragilities that could be exploited by appropriate therapies targeting the DNA repair machinery. The implications of this hypothesis are discussed.
PB Wiley
YR 2014
FD 2014-04
LK https://hdl.handle.net/10630/29836
UL https://hdl.handle.net/10630/29836
LA eng
NO Solé, Ricard V., Sergi Valverde, Carlos Rodriguez‐Caso, and Josep Sardanyés. "Can a minimal replicating construct be identified as the embodiment of cancer?." Bioessays 36, no. 5 (2014): 503-512. doi.org/10.1002/bies.201300098
NO This work was supported by a grant MINECO, the Botin Foundation, and the Santa Fe Institute
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026