RT Journal Article
T1 Nutritional characterization of Cusco green tea and its synergistic effect with omega-3 on metabolic and cognitive dysfunctions in obese rats
A1 Finetti-Casanova, Paola
A1 Bernuy-Osorio, Nataly
A1 Rodriguez-Pozo, Miguel
A1 Maaloul, Aya
A1 Abdala-Díaz, Roberto Teófilo
A1 Decara, Juan
K1 Antiinflamatorios
K1 Obesidad
K1 Acidos grasos omega-3
AB BACKGROUND: Obesity and its metabolic complications, such as insulin resistance and cognitive decline, remain a global healthchallenge. Green tea (Camelia sinensis) and ω-3 polyunsaturated fatty acids (PUFAs) are recognized for their antioxidant, anti-inflammatory, and neuroprotective properties. This study aimed to qualitatively characterize green tea from Cusco, Peru, andevaluate the synergistic effects of its infusion (GTi) and ω-3 supplementation on hyperlipidemia, proinflammatory cytokines,and cognitive impairment in a high-fat diet (HFD) rat model.RESULTS: Nutritional analysis confirmed the high quality of Cusco green tea, showing potent antioxidant activity and a uniquecatechin profile. In obese rats, HFD induced significant weight gain and metabolic dysfunction; supplementation with GTi, ω-3,or their combination significantly improved glucose tolerance and reduced triglyceride and very-low-density lipoprotein levels.Notably, the combined treatment (GTi + ω-3) showed the greatest reduction in plasma TNF-⊍. Behavioral assessments via novelobject recognition tests demonstrated that supplementation alleviated obesity-related cognitive deficits, significantly enhanc-ing both short-term and long-term memory discrimination indices.CONCLUSION: This study highlights the potential of combining Cusco green tea and ω-3 PUFAs as a complementary nutritionalintervention to mitigate hyperlipidemia and cognitive dysfunction associated with obesity. These effects are likely mediatedthrough the modulation of proinflammatory mediators and the enhancement of antioxidant defenses, which help restoreredox homeostasis and protect neuronal integrity.
PB Wiley
YR 2026
FD 2026
LK https://hdl.handle.net/10630/46553
UL https://hdl.handle.net/10630/46553
LA eng
NO Finetti-Casanova, P., Bernuy-Osorio, N., Rodriguez-Pozo, M., Maaloul, A., Abdala-Diaz, R.T. and Decara, J. (2026), Nutritional characterization of Cusco green tea and its synergistic effect with omega-3 on metabolic and cognitive dysfunctions in obese rats. J Sci Food Agric.
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 may 2026