RT Journal Article
T1 Complicaciones postoperatorias en el trasplante hepático. Relación con la mortalidad.
A1 Seller Pérez, Gemma Luisa
A1 Herrera-Gutiérrez, Manuel Enrique
A1 Aragonés Manzanares, Rocío
A1 Muñoz López, Alfonso
A1 Lebrón-Gallardo, Miguel
A1 González Correa, José Antonio
K1 Hígado - Trasplante
K1 Trasplante de órganos, tejidos, etc. - Factores de riesgo
K1 Mortalidad
K1 Cirugía - Complicaciones y secuelas
AB Background and objective: Liver transplant is an effective procedure for fulminant hepatitis or chronic liver disease and offers an adequate quality of life. However, even though it is a consolidated treatment, patients can develop serious complications in the immediate postoperative course.Patients and method: Prospective observational study of 131 patients admitted in our intensive care unit after liver transplant surgery. We studied variables related with the development of complications and their relation to outcome.Results: Intensive care unit mortality was 11.5%. Median stay was 4 days. 90% of patients presented 2 or more complications. Hyperglycemia, thrombocytopenia and hypothermia were the most frequent complications but they were not related with mortality. Less frequent but related to outcome complications were acute renal failure (23.6% mortality vs. 1.3%; p < 0.01), ADRS (63.6% vs 6.7%; p < 0,01), low cardiac output (71.4% vs 4.3%; p < 0.01), > or = 2 vasoactive drugs (61.9% vs 1.8%; p < 0.01), encephalopathy (37.5% vs 9.8%; p < 0.05), pneumonia (80% vs 8%; p < 0.01) and hemorrhage (29.4% vs 8.8%; p < 0.05). Graph ischemia, coagulopathy, reperfusion syndrome and use of blood derivatives during surgery were factors related with the development of complications and mortality. Multivariate analysis showed a relationship with mortality and low cardiac output, number of vasoactive drugs and total time of graft ischemia.Conclusions: Complications during the postoperative course of liver transplant are frequent but most of them have no effect on prognosis. The negative effect of severe complications should be limited by optimizing the hemodynamic support in these patients and minimizing ischemia of transplanted organs.
PB Elsevier
YR 2004
FD 2004-02-24
LK https://hdl.handle.net/10630/41141
UL https://hdl.handle.net/10630/41141
LA spa
NO Seller-Pérez G, Herrera-Gutiérrez ME, Aragonés-Manzanares R, Muñoz-López A, Lebrón-Gallardo M, González-Correa JA. Complicaciones postoperatorias en el trasplante hepático. Relación con la mortalidad [Postoperative complications of liver transplantation: relationship with mortality]. Med Clin (Barc). 2004 Sep 18;123(9):321-7. Spanish. doi: 10.1016/s0025-7753(04)74505-4. PMID: 15388033.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/19939
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026