RT Journal Article
T1 Biomarkers of oxidation, inflammation and intestinal permeability in persons with diabetes mellitus with parenteral nutrition: A multicenter randomized trial
A1 Soria-Utrilla, Virginia
A1 Sasso, Corina Verónica
A1 Romero-Zerbo, Silvana Yanina
A1 Adarve-Castro, Antonio
A1 López-Urdiales, Rafael
A1 Herranz-Antolín, Sandra
A1 García-Almeida, José Manuel
A1 García-Malpartida, Katherine
A1 Ferrer-Gómez, Mercedes
A1 Moreno-Borreguero, Alicia
A1 Luengo-Pérez, Luis Miguel
A1 Álvarez-Hernández, Julia
A1 Aragón-Valera, Carmen
A1 Ocón-Bretón, María Julia
A1 García-Manzanares, Álvaro
A1 Bretón-Lesmes, Irene
A1 Serrano-Aguayo, Pilar
A1 Pérez-Ferre, Natalia
A1 López-Gómez, Juan José
A1 Olivares-Alcolea, Josefina
A1 Moreno-Martínez, Macarena
A1 Tejera-Pérez, Cristina
A1 García-Arias, Sara
A1 García-Arias, Sara
A1 Abad-González, Ángel Luis
A1 Alhambra-Expósito, María Rosa
A1 Zugasti-Murillo, Ana
A1 Parra-Barona, Juan
A1 Torrejón-Jaramillo, Sara
A1 Abuin, José
A1 Fernández-García, José C.
A1 Olveira-Fuster, Gabriel María
K1 Alimentación parenteral
K1 Inflamación (Patología)
K1 Intestinos
K1 Diabetes tipo 2
AB Background and aims: Parenteral nutrition (PN) composition could play a role in the management of systemic inflammatory response and intestinal barrier disruption. We aimed to evaluate changes in biomarkers of inflammation, oxidative status and intestinal permeability in patients with type 2 diabetes mellitus (T2DM) who received different PN lipid formulas. Methods: This was a prospective study, including 94 patients with T2DM who received omega (n)-3 polyunsaturated fatty acids (PUFA)-enriched PN, a mixture of medium and long chain triglycerides (MCT/ LCT) PN, or an olive oil-based PN. Serum levels of biomarkers of oxidative status, intestinal permeability and inflammation biomarkers were determined at day 1 and day 5 after PN initiation. Registered under ClinicalTrials.gov Identifier no. NCT02706119.
AB Results: At day 5 after the onset of PN, the MCT/LCT group had a significant reduction of 2 proinflammatory cytokines [interleukin (IL)-15, IL-17A], elevation of the anti-inflammatory cytokine IL-13 and increase of zonulin and indoxylsulfate. The olive oil group showed a statistically significant reduction of 5 proinflammatory cytokines [IL-1b, IL-17A, IL-6, cytokine-leukemia inhibitory factor (LIF) and tumor necrosis factor alpha (TNF-a)] and reduced concentrations of the anti-inflammatory cytokine IL-1RA, while the n-3 PUFA-enriched group presented a statistically significant reduction of 8 proinflammatory cytokines (interferon-gamma, IL-1b, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, and TNF-a). In the between-group comparisons, indoxylsulfate significantly increased in the MCT/LCT group compared to the n-3 PUFA-enriched group, while 8-isoprostane and indoxylsulfate significantly increased in the MCT/LCT group compared to the other groups and superoxide dismutase significantly decreased in the MCT/LCT group compared to the other groups. Conclusion: In patients with T2DM, PN lipid composition exerts a profound impact on proinflammatory, prooxidative and intestinal permeability biomarkers
PB Elsevier
YR 2025
FD 2025
LK https://hdl.handle.net/10630/39385
UL https://hdl.handle.net/10630/39385
LA eng
NO Soria-Utrilla, V., Sasso, C. V., Romero-Zerbo, S. Y., Adarve-Castro, A., López-Urdiales, R., Herranz-Antolín, S., García-Almeida, J. M., García-Malpartida, K., Ferrer-Gómez, M., Moreno-Borreguero, A., Luengo-Pérez, L. M., Álvarez-Hernández, J., Aragón-Valera, C., Ocón-Bretón, M. J., García-Manzanares, Á., Bretón-Lesmes, I., Serrano-Aguayo, P., Pérez-Ferre, N., López-Gómez, J. J., . . . Olveira, G. (2024). Biomarkers of Oxidation, Inflammation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: a Multicenter Randomized Trial. Clinical Nutrition, 44, 155-164. https://doi.org/10.1016/j.clnu.2024.11.044
NO This work was supported by Instituto de Salud Carlos III (ISCIII, co-funded by Fondo Europeo de Desarrollo Regional [FEDER], European Union [EU], “Una manera de hacer Europa”), Ministerio de Ciencia, Innovacion y Universidades, Gobierno de Espa   na (PI15/ ~ 01034), and Sociedad Andaluza de Endocrinología Diabetes y Nutricion (SAEDYN) 2016 and Sociedad Andaluza de Nutrici   on  Clínica y Dietetica (SANCYD-BAXTER 2021) research project. Centro   de Investigacion Biom   edica en Red (CIBERDEM) is an initiative of   the Instituto de Salud Carlos III. JCF-G was supported by the Intensification Research Program (INT21/00078, ISCIII, Spain; cofunded by the Fondo Europeo de Desarrollo Regional FEDER). CV Sasso is contracted by a María Zambrano grant for the attraction of international talent at the University of M  alaga. The funding organization played no role in the design of the study, review and interpretation of the data, or final approval of the manuscript. Funding for open access publishing: Spanish Society of Endocrinology and Nutrition (SEEN).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026