RT Journal Article
T1 TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis
A1 López-Gómez, Carlos
A1 Fernández, Oscar
A1 García-León, Juan Antonio
A1 Pinto-Medel, María Jesús
A1 Oliver-Martos, Begoña
A1 Ortega-Pinazo, Jesús
A1 Suardíaz-García, Margarita
A1 García-Trujillo, Lucía
A1 Guijarro-Castro, Cristina
A1 Benito-León, Julián
A1 Prat, Isidro
A1 Varadé, Jezabel
A1 Alvarez-Lafuente, Roberto
A1 Urcelay, Elena
A1 Leyva-Fernández, Laura
K1 Esclerosis múltiple-Aspectos genéticos
AB The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10−4, OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10−5, OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS.
PB Public Library of Science
YR 2011
FD 2011-07
LK https://hdl.handle.net/10630/34434
UL https://hdl.handle.net/10630/34434
LA eng
NO López-Gómez C, Fernández Ó, García-León JA, Pinto-Medel MJ, Oliver-Martos B, Ortega-Pinazo J, et al. (2011) TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis. PLoS ONE 6(7): e21766. https://doi.org/10.1371/journal.pone.0021766
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 feb 2026