RT Journal Article T1 Impact of an Early Discharge Hospital-at-Home Program on Length of Stay and Clinical Outcomes in Preterm Infants: A Case-Control Study. A1 García Ortega, María Ángeles A1 García-Piñero, José Miguel A1 Gómez-González, Alberto José A1 Medina López, Rosana A1 González García, Marta A1 Montero-García, Antonio Jesús A1 Morales-Gil, Isabel María K1 Niños prematuros K1 Enfermería neonatal K1 Hospitalización a domicilio K1 Lactancia materna AB Background/Objectives: Prolonged hospitalization of clinically stable preterm infantsmay lead to nosocomial infections, interfere with breastfeeding, and hinder parent-infantbonding. We evaluated the impact of an early discharge program with hospital-at-home(HaH) on hospital stay and clinical outcomes among preterm infants. Methods: A retrospective case–control study was conducted in a tertiary neonatal unit (Spain). Fiftyinfants managed with HaH (2016–2020) were compared with ninety-six controls receivingconventional in-hospital care. Baseline characteristics, growth, and clinical events up to12 months were collected. Analyses included bivariate comparisons and multiple linearregression for length of stay, adjusted for gestational age, birth weight, sex, and parentalfactors. Results: Baseline characteristics were comparable between groups. Dischargeweight was lower in HaH infants (1865 vs. 2130 g; p < 0.001), but no differences wereobserved at 6 or 12 months. Length of stay was shorter in HaH infants (26.3 vs. 33.8 days;p = 0.081), and the multivariable model showed an independent 5.5-day reduction (β −5.53;95% CI −10.96 to −0.11; p = 0.046). Exclusive breastfeeding was more frequent (74% vs.59%; p = 0.08) and significantly longer in HaH infants (141.9 vs. 81.1 days; p = 0.024). Noincreases were found in complications at discharge, emergency visits (28% vs. 32%; p = 0.7),or readmissions (18% vs. 31%; p = 0.2). Conclusions: Among clinically stable preterminfants, early discharge with HaH was associated with a shorter hospital stay and longerexclusive breastfeeding duration, without evidence of increased morbidity or healthcareuse; however, causal inference cannot be established due to the observational design. Thesefindings support the implementation of nurse-led HaH programs as a safe, family-centeredstrategy for neonatal care. PB MDPI YR 2025 FD 2025-11-06 LK https://hdl.handle.net/10630/44660 UL https://hdl.handle.net/10630/44660 LA eng NO García-Ortega, M.Á.; García-Piñero, J.M.; Gómez-González, A.J.; Medina-López, R.; González -García, M.; Montero-García, A.J.; Morales-Gil, I.M. Impact of an Early Discharge Hospital-at-Home Program on Length of Stay and Clinical Outcomes in Preterm Infants: A Case–Control Study. Children 2025, 12, 1504. https://doi.org/10.3390/ children12111504 DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 2 mar 2026