RT Journal Article
T1 Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
A1 Baglietto-Vargas, David
A1 Moreno-González, Inés
A1 Sánchez-Varo, Raquel María
A1 Jiménez, Sebastián
A1 Trujillo-Estrada, Laura Isabel
A1 Sánchez-Mejías, Elisabeth
A1 Torres, Manuel
A1 Romero-Acebal, Manuel
A1 Ruano, Diego
A1 Vizuete, Marisa
A1 Vitorica Ferrández, Javier
A1 Gutiérrez-Pérez, Antonia
K1 Alzheimer, Enfermedad de
K1 Amiloide
K1 Hipocampo (Cerebro)
K1 Sistema nervioso - Enfermedades
K1 Neuronas
K1 Sistema nervioso - Degeneración
AB Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential vulnerability to neurodegeneration in AD. We have previously reported a substantial loss of SOM/NPY interneurons, whereas those expressing parvalbumin were unaltered, in the hippocampus of 6 month-old PS1/AβPP transgenic mice. In the present study, we now investigated the pathological changes of hippocampal calretinin (CR) interneurons in this PS1/AβPP model from 2 to 12 months of age. Thetotal number of CR-immunoreactive inhibitory cells was determined by stereology in CA1 and CA2/3 subfields. Our findings show a substantial decrease (35%–45%) of CR-positive interneurons in both hippocampal subfields of PS1/AβPP mice at very early age (4 months) compared to age-matched control mice. This decrease was accompanied by a reduced CR mRNA content as determined by quantitative RT-PCR. However, the number of another hippocampal CR-positive population (belonging to Cajal-Retzius cells) was not affected. The selective early loss of CR-interneurons was parallel to the appearance of extracellularAβ deposits, preferentially in CR-axonal fields, and the formation of dystrophic neurites. This specific  GABAergic subpopulation plays a crucial role in the generation of synchronous rhythmic activity in hippocampus by controlling other interneurons. Therefore, early alterations of hippocampal inhibitory functionality in AD, caused by select CR-cells neurodegeneration, could result in cognitive impairments seen in initial stages of the disease.
PB IOS Press
YR 2010
FD 2010-07-08
LK https://hdl.handle.net/10630/30764
UL https://hdl.handle.net/10630/30764
LA eng
NO Baglietto-Vargas D, Moreno-Gonzalez I, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A. Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus. J Alzheimers Dis. 2010;21(1):119-32.
NO PI06/0556-PS09/00099 (to AG), PI06/0567-PS09/00151 (to JV), PI06/0781-PS09/00848 (to DR) from Fondo de Investigacion Sanitaria (FIS) -Instituto de Salud Carlos III- Spain. DB-V, IM-G and SJ were the recipients of acontract from CIBERNED. RS-V, ES-M and MT held a PhD fellowship from Spain FPU or FPI programs.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026