RT Journal Article
T1 High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries.
A1 Zoubek, Miguel E.
A1 González-Jiménez, Andrés
A1 Medina-Cáliz, Inmaculada
A1 Robles-Díaz, María Mercedes
A1 Hernandez, Nelia
A1 Romero-Gomez, Manuel
A1 Bessone, Fernando
A1 Hallal, Hacibe
A1 Cubero, Francisco Javier
A1 Lucena-González, María Isabel
A1 Stephens, Camilla
A1 Andrade-Bellido, Raúl Jesús
K1 Hepatotoxicidad
K1 Hígado - Lesiones y heridas
K1 Ibuprofeno - Efectos secundarios
AB Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 3% to 10% of idiosyncratic drug-induced liver injury (DILI) cases in the Western world.1–3 Ibuprofen is a widely prescribed NSAID avail- able as over-the-counter medication (OTC), and perceived as having a better safety profile than many other NSAIDs. Interestingly, striking regional differences in the frequency of ibuprofen hepatotoxicity were noted in a comparison of causative DILI agents among large DILI cohorts in 2010.4 Based on the limited information available on this type of DILI, we aimed to analyze the clinical presentation of ibuprofen-associated hepatotox- icity in the search for a potential drug signature.
PB Elsevier
YR 2018
FD 2018-02
LK https://hdl.handle.net/10630/40286
UL https://hdl.handle.net/10630/40286
LA eng
NO Zoubek ME, González-Jimenez A, Medina-Cáliz I, Mercedes Robles-Díaz, Hernandez N, Romero-Gómez R, Bessone F, Hallal H, Cubero FJ, Lucena MI, Stephens C, Andrade RJ. High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries. Clin Gastroenterol Hepatol 2018 Feb;16(2):292-294
NO https://openpolicyfinder.jisc.ac.uk/id/publication/4740
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026