RT Journal Article
T1 Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain
A1 González-Doménech, Carmen María
A1 Viciana-Ramos, María Isabel
A1 Palacios-Muñoz, María Rosario
A1 Delgado, Marcial
A1 Del Arco, Alfonso
A1 Tellez, Francisco
A1 Jarilla, Francisco
A1 Fernández, Sonsoles
A1 Clavijo-Frutos, Encarnación
A1 Santos-González, Jesús Leandro
K1 Virus del SIDA
AB Background: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain. This strain was detected in treatment-naive patients from southern Spain.Methods: The study was undertaken at the Virgen de la Victoria Hospital, Malaga, a reference centre for the study of HIV-1 genotype resistance in Andalusia (the 'Costa del Sol'), Spain. Genotypic resistance testing was done in an automated sequencer. Phylogenetic analysis was performed using a 630 bp region of the reverse transcriptase with the mutations mentioned.Results: Between 2007 and 2014, we detected the Malaga strain in 30 treatment-naive patients. All were MSM, seen at five hospitals on the Costa del Sol. In all cases, the HIV-1 was subtype B with viral tropism R5. Phylogenetic analysis based on the reverse transcriptase sequence showed consistent grouping (with a bootstrap value of the common node of 100%) of the isolates that shared the mutation pattern mentioned. This strain has not been detected elsewhere or in previously treated patients. All of the patients treated with first-line combination ART responded.Conclusions: We report a cluster of an HIV-1 strain with multiple resistance mutations that was transmitted over a period of >8 years, affecting 30 naive patients from the same geographical area. The strain was susceptible to first-line combination ART.
PB Oxford Academic
YR 2016
FD 2016-02
LK https://hdl.handle.net/10630/29113
UL https://hdl.handle.net/10630/29113
LA eng
NO Viciana I, González-Domenech CM, Palacios R, Delgado M, Del Arco A, Tellez F, Jarilla F, Fernández S, Clavijo E, Santos J. Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain. J Antimicrob Chemother. 2016 Feb;71(2):357-61. doi: 10.1093/jac/dkv332.
NO Partially funded by the RD12/0017/0017 project (Plan Nacional R+D+I) and cofinanced by Instituto de Salud Carlos III-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 23 ene 2026