RT Journal Article
T1 Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome
A1 Vinicki, Martina
A1 Pribić, Tea
A1 Vučković, Frano
A1 Frkatović‑Hodžić, Azra
A1 Plaza-Andrades, Isaac
A1 Tinahones-Madueño, Francisco José
A1 Raffaele, Joseph
A1 Fernández-García, José Carlos
A1 Lauc, Gordan
K1 Medicina clínica
AB With aging, the body’s ability to maintain regular functions declines, increasing susceptibility to age-related diseases. Therapeutic interventions targeting the underlying biological changes of aging hold promise for preventing or delaying multiple age-related diseases. Metformin, a drug commonly used for diabetes treatment, has emerged as a potential gerotherapeutic agent due to its established safety record and preclinical and clinical data on its anti-aging effects. Glycosylation, one of the most common and complex co- and post-translational protein modifications, plays a crucial role in regulating protein function and has been linked to aging and various diseases. Changes in immunoglobulin G (IgG) glycosylation patterns have been observed with age, and these alterations may serve as valuable biomarkers for disease predisposition, diagnosis, treatment monitoring, and overall health assessment. In this study, we analyzed the IgG glycosylation patterns of white men from Europe, aged 29–45 years, under treatment with metformin, testosterone, metformin plus testosterone, and placebo (trial registration number NCT02514629, 2013/07/04), and investigated the longitudinal changes in glycosylation over time. We observed statistically significant differences in the IgG glycome composition between participants on testosterone therapy and placebo, with decreased agalactosylation and increased galactosylation and sialylation. However, metformin therapy did not result in statistically significant changes in glycosylation patterns. These findings contribute to our understanding of the impact of therapeutic interventions on IgG glycosylation and confirm the value of IgG glycosylation as a significant biomarker, capable of assessing biological age using the GlycanAge index and providing insight into overall health compared to chronological age.
PB Springer
YR 2024
FD 2024
LK https://hdl.handle.net/10630/34781
UL https://hdl.handle.net/10630/34781
LA eng
NO Vinicki, M., Pribić, T., Vučković, F. et al. Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome. GeroScience (2024). https://doi.org/10.1007/s11357-024-01349-z
NO Funding for open access charge: Universidad de Málaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 23 ene 2026