RT Journal Article
T1 Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
A1 Yu, Daqi
A1 Ren, Yandong
A1 Uesaka, Masahiro
A1 Beavan, Alan J. S.
A1 Muffato, Matthieu
A1 Shen, Jieyu
A1 Li, Yongxin
A1 Sato, Iori
A1 Wan, Wenting
A1 Clark, James W.
A1 Keating, Joseph N.
A1 Carlisle, Emily M.
A1 Dearden, Richard P.
A1 Giles, Sam
A1 Randle, Emma
A1 Sansom, Robert S.
A1 Feuda, Roberto
A1 Fleming, James F.
A1 Sugahara, Fumiaki
A1 Cummins, Carla
A1 Patricio, Mateus
A1 Akanni, Wasiu
A1 D'Aniello, Salvatore
A1 Bertolucci, Cristiano
A1 Irie, Naoki
A1 Alev, Cantas
A1 Sheng, Guojun
A1 de Mendoza, Alex
A1 Maeso, Ignacio
A1 Irimia, Manuel
A1 Fromm, Bastian
A1 Peterson, Kevin J.
A1 Das, Sabyasachi
A1 Hirano, Masayuki
A1 Rast, Jonathan P.
A1 Cooper, Max D.
A1 Paps, Jordi
A1 Pisani, Davide
A1 Kuratani, Shigeru
A1 Martin, Fergal J.
A1 Wang, Wen
A1 Donoghue, Philip C. J.
A1 Zhang, Yong E.
A1 Pascual-Anaya, Juan
K1 Vertebrados - Evolución
AB Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis suggests that two WGD events (1R and 2R) occurred during early vertebrate evolution. However, the timing of the 2R event relative to the divergence of gnathostomes ( jawed vertebrates) and cyclostomes ( jawless hagfishes and lampreys) is unresolved and whether these WGD events underlie vertebrate phenotypic diversification remains elusive. Here we present the genome of the inshore hagfish, Eptatretus burgeri. Through comparative analysis with lamprey and gnathostome genomes, we reconstruct the early events in cyclostome genome evolution, leveraging insights into the ancestral vertebrate genome. Genome-wide synteny and phylogenetic analyses support a scenario in which 1R occurred in the vertebrate stem-lineage during the early Cambrian, and 2R occurred in the gnathostome stem-lineage, maximally in the late Cambrian–earliest Ordovician, after its divergence from cyclostomes. We find that the genome of stem-cyclostomes experienced an additional independent genome triplication. Functional genomic and morphospace analyses demonstrate that WGD events generally contribute to developmental evolution with similar changes in the regulatory genome of both vertebrate groups. However, appreciable morphological diversification occurred only in the gnathostome but not in the cyclostome lineage, calling into question the general expectation that WGDs lead to leaps of bodyplan complexity.
PB Springer Nature
YR 2024
FD 2024-03
LK https://hdl.handle.net/10630/32703
UL https://hdl.handle.net/10630/32703
LA eng
NO u, D., Ren, Y., Uesaka, M. et al. Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences. Nat Ecol Evol 8, 519–535 (2024). https://doi.org/10.1038/s41559-023-02299-z
NO Ministerio de Ciencia e Innovación, proyecto con referencia PID2021-125078NA-I00.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026