RT Journal Article
T1 Advancements in long-read genome sequencing technologies  and algorithms.
A1 Espinosa García, Elena María
A1 Bautista-Moreno, Rocío
A1 Larrosa-Jiménez, Rafael
A1 Plata-González, Óscar Guillermo
K1 Bioinformática
AB The recent advent of long read sequencing technologies, such as Pacific Biosciences (PacBio) and Oxford Nanopore technology (ONT), have led to substantial improvements in accuracy and computational cost in sequencing genomes. However, de novo whole-genome assembly still presents significant challenges related to the quality of the results. Pursuing de novo whole-genome assembly remains a formidable challenge, underscored by intricate considerations surrounding computational demands and result quality. As sequencing accuracy and throughput steadily advance, a continuous stream of innovative assembly tools floods the field. Navigating this dynamic landscape necessitates a reasonable choice of sequencing platform, depth, and assembly tools to orchestrate high-quality genome reconstructions. This comprehensive review delves into the intricate interplay between cutting-edge long read sequencing technologies, assembly methodologies, and the ever-evolving field of genomics. With a focus on addressing the pivotal challenges and harnessing the opportunities presented by these advancements, we provide an in-depth exploration of the crucial factors influencing the selection of optimal strategies for achieving robust and insightful genome assemblies.
PB Elsevier
YR 2024
FD 2024-03
LK https://hdl.handle.net/10630/31051
UL https://hdl.handle.net/10630/31051
LA eng
NO Espinosa, E., Bautista, R., Larrosa, R., & Plata, O. (2024). Advancements in long-read genome sequencing technologies and algorithms. Genomics (San Diego, Calif.), 110842-.
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026