RT Journal Article
T1 Isolation and Antitumoral Effect of a New Siphonochilone Derivative from African Ginger.
A1 Fuentes-Ríos, David
A1 Ortigosa, Alba
A1 Quiñonero, Francisco
A1 Melguizo, Consolación
A1 Ortiz, Raúl
A1 Prados, José
A1 Díaz-Morilla, Amelia
A1 López-Romero, Juan Manuel
K1 Productos naturales
K1 Compuestos bioactivos vegetales
K1 Antineoplásicos
K1 Jengibre - Uso terapeútico
AB A new eusdesmane sesquiterpenoid, characterized as 3,5,8a-trimethyl-8-oxo-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan-5-yl acetate (1), has been isolated from the rhizomes of the South African variety of wild ginger (Siphonochilus aethiopicus(Schweinf) B. L. Burtt). The compound was obtained by silica gel column chromatography. Its structure was elucidated by nuclearmagneticresonance spectroscopy(NMR) and mass-spectrometric (MS)analyses, including 1D-, 2D-NMR,and HR-LCMS. We alsoinvestigated the cytotoxic effect of 1 on a panel of cancer cell lines, human breast, pancreas, lung, colon, and central nervous systemcancer lines. The data are not encouraging since its antitumor effect is poor. Nonetheless, the discovery of new molecules mayprovide a source of new compounds with important biological effects applicable to the field of medicine.
PB ACS
YR 2024
FD 2024-03-20
LK https://hdl.handle.net/10630/40478
UL https://hdl.handle.net/10630/40478
LA eng
NO ACS Omega 2024, 9, 15718−15722
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026