RT Journal Article
T1 Suppression of NLR-mediated plant immune detection by bacterial pathogens.
A1 Rufián Plaza, José Sebastián
A1 Rueda-Blanco, Javier
A1 Beuzón-López, Carmen del Rosario
A1 Ruiz-Albert, Francisco Javier
K1 Bacterias fitopatógenas
K1 Plantas - Metabolismo
AB The plant immune system is constituted of two functionally interdependent branches that provide the plant with aneffective defense against microbial pathogens. They can be considered separate since one detects extracellularpathogen-associated molecular patterns by means of receptors on the plant surface, while the other detects pathogen-secreted virulence effectors via intracellular receptors. Plant defense depending on both branches can be effectivelysuppressed by host-adapted microbial pathogens. In this review we focus on bacterially driven suppression ofthe latter, known as effector-triggered immunity (ETI) and dependent on diverse NOD-like receptors (NLRs). We examinehow some effectors secreted by pathogenic bacteria carrying type III secretion systems can be subject to specificNLR-mediated detection, which can be evaded by the action of additional co-secreted effectors (suppressors),implying that virulence depends on the coordinated action of the whole repertoire of effectors of any given bacteriumand their complex epistatic interactions within the plant. We consider how ETI activation can be avoided by usingsuppressors to directly alter compromised co-secreted effectors, modify plant defense-associated proteins, or occasionallyboth. We also comment on the potential assembly within the plant cell of multi-protein complexes comprisingboth bacterial effectors and defense protein targets.
PB Oxford University Press
YR 2023
FD 2023
LK https://hdl.handle.net/10630/35689
UL https://hdl.handle.net/10630/35689
LA eng
NO Rufián JS, Rueda-Blanco J, Beuzón CR, Ruiz-Albert J. Suppression of NLR-mediated plant immune detection by bacterial pathogens. J Exp Bot. 2023 Oct 13;74(19):6069-6088
NO Project Grant PID2021-127245OB-I00 financed by MCIN/AEI/10.13039/501100011033/ and ‘ERDP A way of making Europe’.Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020).Project Grant UMA20-FEDERJA-021 (Programa Operativo Fondos Europeos de Desarrollo Regional Andalucía).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026