RT Journal Article
T1 Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.
A1 López-Noriega, Livia
A1 Capilla-González, Vivian
A1 Cobo-Vuilleumier, Nadia
A1 Martin-Vazquez, Eugenia
A1 Isabel Lorenzo, Petra
A1 Martinez-Force, Enrique
A1 Soriano-Navarro, Mario
A1 García-Fernández, María
A1 Romero-Zerbo, Silvana Yanina
A1 Bermúdez Silva, Francisco Javier
A1 Díaz-Contreras, Irene
A1 Sánchez-Cuesta, Ana
A1 Santos-Ocaña, Carlos
A1 Hmadcha, Abdelkrim
A1 Soria, Bernat
A1 Martín, Franz
A1 Gauthier, Benoit Raymond
A1 Martin-Montalvo, Alejandro
K1 Tiroides
K1 Hipotiroidismo
K1 Hipertiroidismo
K1 Tirotropina
AB An inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed as a biomarker for healthy aging and metabolic fitness. However, hypothyroidism is a medical condition associated with compromised health and reduced life expectancy. Herein, we show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and shorter lifespan. Mild hypothyroid Pax8 +/- mice were heavier and displayed insulin resistance, hepatic steatosis and increased prevalence of liver cancer yet had normal lifespan. These pathophysiological conditions were precipitated by hepatic mitochondrial dysfunction and oxidative damage accumulation. These findings indicate that individuals carrying mutations on PAX8 may be susceptible to develop liver cancer and/or diabetes and raise concerns regarding the development of interventions aiming to modulate thyroid hormones to promote healthy aging or lifespan in mammals.
PB Impact Journals
YR 2019
FD 2019
LK https://hdl.handle.net/10630/39319
UL https://hdl.handle.net/10630/39319
LA eng
NO Aging (Albany NY). 2019 Sep 13;11(18):7746-7779.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 14 abr 2026