RT Journal Article
T1 A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats
A1 Masmudi-Martín, Mariam
A1 López-Aranda, Manuel Francisco
A1 Navarro-Lobato, Irene
A1 Khan, Zafaruddin
AB Perirhinal cortex is a brain area that has been considered crucial for the object recognition memory (ORM). However, with the use of an ORM enhancer named RGS14414 as gain-in-function tool, we show here that frontal association cortex and not the Perirhinal cortex is essential for the ORM of objects with complex features that consisted of detailed drawing on the object surface (complex ORM). An expression of RGS14414, in rat brain frontal association cortex, induced the formation of long-term complex ORM, whereas the expression of the same memory enhancer in Perirhinal cortex failed to produce this effect. Instead, RGS14414 expression in Perirhinal cortex caused the formation of ORM of objects with simple features that consisted of the shape of object (simple ORM). Further, a selective elimination of frontal association cortex neurons by treatment with an immunotoxin Ox7-SAP completely abrogated the formation of complex ORM. Thus, our results suggest that frontal association cortex plays a key role in processing of a high-order recognition memory information in brain.
PB Federation of European Neuroscience Societies
YR 2024
FD 2024-01-18
LK https://hdl.handle.net/10630/45565
UL https://hdl.handle.net/10630/45565
LA eng
NO Masmudi-Martín M, López-Aranda MF, Navarro-Lobato I, Khan ZU. A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats. Eur J Neurosci. 2024;59(7):1743-1752. doi:10.1111/ejn.16243
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 2 mar 2026