RT Journal Article
T1 Inflammatory Biomarkers in the Diagnosis and Prognosis of Rheumatoid Arthritis–Associated Interstitial Lung Disease
A1 Mena-Vázquez, Natalia
A1 Godoy-Navarrete, Francisco Javier
A1 Lisbona-Montañez, José Manuel
A1 Redondo-Rodríguez, Rocío
A1 Manrique-Arija, Sara
A1 Rioja, Jose
A1 Mucientes, Arkaitz
A1 Ruiz-Limón, Patricia
A1 García-Studer, Aimara
A1 Ortiz-Marquez, Fernando
A1 Oliver-Martos, Begoña
A1 Cano-García, Laura
A1 Fernández-Nebro, Antonio
K1 Marcadores bioquímicos
K1 Artritis reumatoide
AB This study aimed to identify inflammatory factors and soluble cytokines that act as biomarkersin the diagnosis and prognosis of rheumatoid arthritis-associated interstitial lung disease (RAILD).We performed a nested prospective observational case–control study of patients with RA-ILDmatched by sex, age, and time since the diagnosis of RA. All participants underwent pulmonaryfunction testing and high-resolution computed tomography. ILD was defined according to the criteriaof the American Thoracic Society/European Respiratory Society; the progression of lung disease wasdefined as the worsening of FVC > 10% or DLCO > 15%. Inflammation-related variables includedthe inflammatory activity measured using the DAS28-ESR and a multiplex cytokine assay. TwoCox regression models were run to identify factors associated with ILD and the progression of ILD.The study population comprised 70 patients: 35 patients with RA-ILD (cases) and 35 RA patientswithout ILD (controls). A greater percentage of cases had higher DAS28-ESR (p = 0.032) and HAQvalues (p = 0.003). The variables associated with RA-ILD in the Cox regression analysis were diseaseactivity (DAS28) (HR [95% CI], 2.47 [1.17–5.22]; p = 0.017) and high levels of ACPA (HR [95% CI],2.90 [1.24–6.78]; p = 0.014), IL-18 in pg/mL (HR [95% CI], 1.06 [1.00–1.12]; p = 0.044), MCP-1/CCL2 inpg/mL (HR [95% CI], 1.03 [1.00–1.06]; p = 0.049), and SDF-1 in pg/mL (HR [95% CI], 1.00 [1.00–1.00];p = 0.010). The only variable associated with the progression of ILD was IL-18 in pg/mL (HR [95% CI],1.25 [1.07–1.46]; p = 0.004). Our data support that the inflammatory activity was higher in patientswith RA-ILD than RA patients without ILD. Some cytokines were associated with both diagnosis andpoorer prognosis in patients with RA-ILD.
PB MDPI
YR 2023
FD 2023-04-05
LK https://hdl.handle.net/10630/35655
UL https://hdl.handle.net/10630/35655
LA eng
NO Mena-Vázquez, N.; Godoy-Navarrete, F.J.; Lisbona-Montañez, J.M.; Redondo-Rodriguez, R.; Manrique-Arija, S.; Rioja, J.; Mucientes, A.; Ruiz-Limón, P.; Garcia-Studer, A.; Ortiz-Márquez, F.; et al. Inflammatory Biomarkers in the Diagnosis and Prognosis of Rheumatoid Arthritis–Associated Interstitial Lung Disease. Int. J. Mol. Sci. 2023, 24, 6800. https://doi.org/ 10.3390/ijms24076800
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026