RT Journal Article
T1 Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases
A1 Masmudi-Martín, Mariam
A1 Navarro-Lobato, Irene
A1 López-Aranda, Manuel Francisco
A1 Browning, Philip G. F.
A1 Simon, Ana María
A1 López-Téllez, Juan Félix
A1 Jiménez Recuerda, Inmaculada
A1 Martín-Montañez, Elisa
A1 Pérez-Mediavilla, Alberto
A1 Frechilla, Diana
A1 Baxter, Mark G.
A1 Khan, Zafaruddin
K1 Alzheimer, Enfermedad de - Modelos animales
K1 Memoria - Trastornos
AB The integrity of the perirhinal cortex (PRh) is essential for object recognition memory (ORM) function, and damage to this brain area in animals and humans induces irreversible ORM deficits. Here, we show that activation of area V2, a brain area interconnected with brain circuits of ventral stream and medial temporal lobe that sustain ORM, by expression of regulator of G-protein signaling 14 of 414 amino acids (RGS14414) restored ORM in memory-deficient PRh-lesioned rats and nonhuman primates. Furthermore, this treatment was sufficient for full recovery of ORM in rodent models of aging and Alzheimer's disease, conditions thought to affect multiple brain areas. Thus, RGS14414-mediated activation of area V2 has therapeutic relevance in the recovery of recognition memory, a type of memory that is primarily affected in patients or individuals with symptoms of memory dysfunction. These findings suggest that area V2 modulates the processing of memory-related information through activation of interconnected brain circuits formed by the participation of distinct brain areas.
PB Elsevier
YR 2020
FD 2020-09-06
LK https://hdl.handle.net/10630/39253
UL https://hdl.handle.net/10630/39253
LA eng
NO Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, et al. Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer's Diseases. Neuroscience. 2020;448:287-298. doi:10.1016/j.neuroscience.2020.08.039
NO https://openpolicyfinder.jisc.ac.uk/id/publication/15868
NO This research was supported by grants from the Ministerio de Economı´a y Competitividad (BFU2013-43458-R) and Junta de Andalucia (P12-CTS-1694 and PI-0542-2013) to Z.U.K.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026