RT Journal Article
T1 Synthesis, characterization and antitumor activity of a poly-4-Vinyl pyridine-co-cannabidiol polymer
A1 Fuentes-Ríos, David
A1 Moya-Utrera, Federico
A1 Moreno, Javier
A1 Mesas, Cristina
A1 Doña Flores, Manuel
A1 Sarabia-García, Francisco Ramón
A1 López-Romero, Juan Manuel
A1 Melguizo, Consolación
A1 Prados, José
K1 Química inorgánica
K1 Cancer
K1 Polímeros
AB Due to its natural origin and numerous beneficial properties, cannabidiol (CBD), one of the major phytocannabinoids of the Cannabis sativa L., has attracted the attention of many research groups in recent years. In this work, we prepared 4-vinylpyridine (4VP) and CBD co-polymeric nanoparticles (solid@poly-4VP-co-CBD) using N,N’-methylenbisacrylamide (BIS) as cross-linker, and in which CBD is covalently incorporated into the polymeric structure. We evaluated particle morphology by Transmission Electron Microscopy (TEM), while compositional analyses were carried out by Nuclear Magnetic Resonance (NMR) spectroscopy, MALDI mass spectrometry, and Raman and Energy Dispersive X-Ray (EDX) spectroscopies. Moreover, the antitumor effect was analyzed in A549 human lung cell lines, using cell cycle analysis and antiproliferative assays. Interestingly, the polymeric drug retained the cytotoxic and antiproliferative effects of CBD. This fact shows that the solid@poly-4VP-co-CBD system can be considered as a new polymeric drug (PD) and may have an enormous potential since it can make up for the shortcomings of the use of free drugs such as low stability or bioavailability.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/10630/34520
UL https://hdl.handle.net/10630/34520
LA eng
NO David Fuentes-Ríos, Federico Moya-Utrera, Javier Moreno, Cristina Mesas, Manuel Doña-Flores, Francisco Sarabia, J. Manuel López-Romero, Consolación Melguizo, José Prados, Synthesis, characterization and antitumor activity of a poly-4-Vinyl pyridine-co-cannabidiol polymer, European Polymer Journal, Volume 219, 2024, 113328, ISSN 0014-3057, https://doi.org/10.1016/j.eurpolymj.2024.113328.
NO Funding for open access charge: Universidad de Málaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026