RT Journal Article
T1 Potential Antioxidant and Neuroprotective Effect of Polysaccharide Isolated from Digüeñe Cyttaria espinosae.
T2 MDPI
A1 Pérez Manríquez, Claudia
A1 Figueroa, Fabián A.
A1 Tello, Ignacio
A1 Abdala-Díaz, Roberto Teófilo
A1 Mari-Beffa, Manuel
A1 Salazar-Vidal, Viviana
A1 Becerra-Ratia, José
A1 Gavilán, Javiera
A1 Fuentealba, Jorge
K1 Hongos medicinales
K1 Polisacáridos
K1 Péptidos
K1 Alzheimer, Enfermedad de - Tratamiento - Modelos animales
AB Alzheimer’s disease (AD) is a significant global health challenge, further exacerbated bythe anticipated increase in prevalence in the coming years. The accumulation of β-amyloidpeptide plays a critical role in the onset of AD; however, emerging evidence suggests thatsoluble oligomers of β-amyloid may primarily drive the neuronal impairments associatedwith this condition. Additionally, neurodegenerative diseases like AD are linked to oxidativestress and reduced antioxidant capacity in the brain. Natural products, particularlypolysaccharides extracted from mushrooms, have garnered interest due to their neuroprotectiveproperties and the potential to enhance the value of natural sources in addressinghuman diseases. This study examines the antioxidant and neuroprotective properties ofpolysaccharides derived from Cyttaria espinosae Lloyd (CePs), a relatively underexploredfungus native to Chile. Using Fourier Transform Infrared Spectroscopy (FT-IR) and GasChromatography-Mass Spectrometry (GC-MS), we characterized CePs. We assessed theirantioxidant capacity using DPPH and ABTS assays, yielding maximum inhibition ratesof 32.14% and 19.10%, respectively, at a concentration of 10 mg mL−1. CePs showed notoxicity in zebrafish embryos and maintained high cell viability in PC-12 cells exposed toamyloid β peptide (Aβ). Our findings suggest that CePs exhibit significant antioxidant andneuroprotective properties against Aβ peptide toxicity while remaining non-toxic to zebrafishembryos. This underscores the potential of the polysaccharides from this mushroomto serve as functional foods that mitigate oxidative stress and warrant further investigationinto their mechanisms in the context of the physiopathology of Alzheimer’s disease.
PB MDPI
YR 2025
FD 2025-08-29
LK https://hdl.handle.net/10630/40108
UL https://hdl.handle.net/10630/40108
LA eng
NO Pérez, C., Figueroa, F. A., Tello, I., Abdala-Díaz, R. T., Marí-Beffa, M., Salazar-Vidal, V., Becerra, J., Gavilán, J., & Fuentealba, J. (2025). Potential Antioxidant and Neuroprotective Effect of Polysaccharide Isolated from Digüeñe Cyttaria espinosae. Journal of fungi (Basel, Switzerland), 11(9), 637. https://doi.org/10.3390/jof11090637
NO Agencia Nacional de Investigación y Desarrollo (ANID)
NO Gobierno Andaluz
NO Fondo Europeo de Desarrollo Regional
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026